Emotional distress and quality of life during folinic acid, fluorouracil, and oxaliplatin in colorectal cancer patients with and without chemotherapy-induced peripheral neuropathy: A cross-sectional study

This study compared emotional distress and QOL during FOLFOX in CRC patients with and without CIPN symptoms. This cross-sectional, descriptive, and comparative study recruited 68 CRC patients receiving FOLFOX at a local teaching hospital and at a medical center in southern Taiwan. Self-reported structured questionnaires (oxaliplatin-associated neuropathy questionnaire, profile of mood states short form, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30, version 3.0) were used for 1-time data collection. The Chi-square test, Fisher exact test, and Mann–Whitney U test were used to analyze data, and a P-value 
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

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Conclusion: The results of our unsupervised classification algorithm based on three variables of laboratory tests correlated well with the neurologists' diagnoses. PMID: 32076460 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Colorectal cancer is the most common cancer in Hong Kong. Oxaliplatin-based chemotherapy is a major first-line conventional therapy for advanced and metastatic colorectal cancer. However, oxaliplatin causes ch...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
This study aims to evaluate the efficacy and safety of the concurrent use of two complementary and alternative therapies: electroacupuncture (EA) and Chuna manual therapy (CMT), with pregabalin, which is the conventional pharmacotherapy for neuropathic pain. Methods/design: This is an open-label, parallel, assessor-blinded randomized controlled trial, which includes 90 patients with colorectal and breast cancer, who developed CIPN. After a 2-week preparation period, the patients are divided into three groups (pregabalin administration group, pregabalin + EA treatment group, and pregabalin + CMT treatment group), treated...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
In conclusion, Melatonin possesses an antioxidant effect that can protect the sciatic nerve from degeneration and potentiate VCR's anticancer effect at the same time.
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, MAG prevents the appearance of sensitive axonal neuropathy and neuromuscular disorders induced by oxaliplatin without affecting its antitumor activity. PMID: 31741707 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study was conducted to identify the changes in oxaliplatin-induced peripheral neuropathy (OIPN), disturbance in activities of daily living (ADL), and depression and their interrelationships during the cancer care trajectory in colorectal cancer patients.
Source: European Journal of Oncology Nursing - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: These results suggest that chemotherapy is highly associated with OIPN, disturbance in ADL by OIPN, and depression in colorectal cancer patients. Nursing intervention is needed to relieve depression as well as OIPN in patients undergoing chemotherapy. PMID: 31751847 [PubMed - as supplied by publisher]
Source: European Journal of Oncology Nursing - Category: Nursing Authors: Tags: Eur J Oncol Nurs Source Type: research
Conditions:   Colorectal Cancer;   Chemotherapy-induced Peripheral Neuropathy Interventions:   Drug: Calmangafodipir (5 µmol/kg);   Other: Placebo Sponsors:   PledPharma AB;   Solasia Pharma K.K. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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