Neuromyelitis Optica Spectrum Disorder Coexisting with Ankylosing Spondylitis: A case report

We describe the case of a 46-year-old Chinese female, with one-year history of optic neuritis, was admitted to our hospital with a complaint of bilateral lower limbs and perineum numbness for one month. AQP4-IgG antibodies were positive in both the serum and cerebrospinal fluid of the patient. Additionally, HLA-B27 was positive in the serum. Contrast-enhanced computed tomography scan revealed bilateral sacroiliitis. Magnetic resonance imaging of the spinal cord showed T2 hyperintense lesions in conus medullaris, C8-T1 and T11 of spinal cord. The patient's symptom improved after twice methylprednisolone and mycophenolate mofetil treatment. To our best knowledge, this is the first reported case of concomitant AQP4-positive NMOSD and HLA-B27-positive AS. Systematic studies on the association of NMOSD and AS are needed to clarify whether this coincidence is just a casual phenomenon or whether it points to a yet undiscovered link.Graphical Abstract
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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ConclusionsWhole-body cryotherapy is a useful method to improve standard pharmacological treatment. The WBC intervention reduces mental health deterioration, especially in mood disorders, such as depression, and can be beneficial for well-being and quality of life.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Authors: Fonti GL, Chimenti MS, Greco E, Boffa L, Conigliaro P, Triggianese P, Perricone R PMID: 32452349 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Macaluso F, Guggino G, Ciccia F PMID: 32452343 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Jeiri Flores is normally a busy, upbeat 29-year-old. But amid the COVID-19 pandemic, her go-to thought has been dark. “If I get this,” she thinks, “I’m gonna die.” This is not an unfounded fear. Flores has cerebral palsy, uses a wheelchair and needs assistance with everyday tasks, including making food and getting dressed. Her disability means it’s tougher for her immune system to kick illnesses; she’s still recovering from a bout of pneumonia she had in January. So beating COVID-19 could easily mean a protracted battle and months in a hospital—a prospect that comes with a c...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Publication date: Available online 15 November 2019Source: Autoimmunity ReviewsAuthor(s): José María G. Ruiz de Morales, Lluís Puig, Esteban Daudén, Juan D. Cañete, José Luis Pablos, Antonio Olveira Martín, Carlos González Juanatey, Alfredo Adán, Xavier Montalbán, Natalia Borruel, Guillermo Ortí, Esther Holgado Martín, Carolina García-Vidal, Cynthia Vizcaya Morales, Víctor Martín Vázquez, Miguel Ángel González-GayAbstractInterleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
We report the clinical cases of two patients affected by a CNS demyelinating disease and ankylosing spondylitis who were successfully treated with secukinumab, providing additional evidence of the feasibility of this therapeutic option when the use of TNF inhibitors is discouraged by challenging comorbidities.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We report the clinical cases of two patients affected by a CNS demyelinating disease and ankylosing spondylitis who were successfully treated with secukinumab, providing additional evidence of the feasibility of this therapeutic option when the use of TNF inhibitors is discouraged by challenging comorbidities.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Purpose of review Sarcoidosis is an immune-mediated disease of unknown cause. Immune-mediated diseases appear to cluster in patients and in families. We review what is known on this topic for sarcoidosis, and what factors may underlie disease clustering. Recent findings In populations of patients with sarcoidosis, relative risk estimates of Sjögren's syndrome, systemic lupus erythematosus, autoimmune hepatitis, ankylosing spondylitis, multiple sclerosis (MS), celiac disease, autoimmune thyroid disease, and ulcerative colitis, varied between 2.1 and 11.6. In relatives of patients with sarcoidosis, relative risk es...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: SARCOIDOSIS: Edited by Jan C. Grutters and Marc A. Judson Source Type: research
CONCLUSION: Based on our systematic review, the epidemiology of IMIDs among immigrants varies according to native and host countries, immigrant generation, and IMID type. The rapid evolution suggests a role for non-genetic factors and gene-environment interactions. Future studies should focus on these pattern shifts, given implications of rising global burden of IMIDs and immigration. PMID: 31351784 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Authors: Macaluso F, Guggino G, Mauro D, Rizzo C, Bignone R, Ciccia F PMID: 31287406 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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