Seronegative antiphospholipid syndrome: refining the value of non-criteria antibodies for the diagnosis and clinical management.

Seronegative antiphospholipid syndrome: refining the value of non-criteria antibodies for the diagnosis and clinical management. Haematologica. 2020 Jan 30;: Authors: Pignatelli P, Ettorre E, Menichelli D, Pani A, Violi F, Pastori D Abstract Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombotic manifestations and/or pregnancy-related complications in patients with persistently high antiphospholipid antibodies (aPL), the most common being represented by anticardiolipin antibodies (aCL), anti-beta 2 glycoprotein-I (aβ2GPI) and lupus anticoagulant (LAC). A growing number of studies showed that in some cases patients may present with clinical features of APS but with temporary positive or persistently negative titers of aPL. For these patients, the definition of seronegative APS (SN-APS) has been proposed. Nevertheless, the negativity to classic criteria aPL, does not imply that other antibodies may be present and involved in the onset of thrombosis. The diagnosis of SN-APS is usually made by exclusion, but its recognition is important to adopt the most appropriate anti-thrombotic strategy to reduce the rate of recurrences. This research is in continuous development as the clinical relevance of these antibodies is far from being completely clarified. The most studied antibodies are those against phosphatidylethanolamine, phosphatidic acid, phosphatidylserine, phosphatidylinosito...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research