A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo [Microbiology]
There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination and existing treatments are only moderately effective. We previously engineered a lectin, H84T banana lectin (H84T), to retain broad-spectrum activity against multiple influenza strains, including pandemic and avian, while largely eliminating the potentially harmful mitogenicity of the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Evelyn M. Coves–Datson, Steven R. King, Maureen Legendre, Auroni Gupta, Susana M. Chan, Emily Gitlin, Vikram V. Kulkarni, Jezreel Pantaleon Garcia, Donald F. Smee, Elke Lipka, Scott E. Evans, E. Bart Tarbet, Akira Ono, David M. Markovitz Tags: Biological Sciences Source Type: research
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