Childhood Anaphylaxis: State of the Art

AbstractPurpose of the ReviewAnaphylaxis is a systemic immunologic reaction of immediate hypersensitivity that occurs as consequence of an interaction between antigen and immunoglobulin E (IgE) and may be potentially fatal. Anaphylaxis symptoms usually occur minutes or seconds after the exposure to the causing allergen. The sooner the reaction is established, the more severe it is. The main causes in children are food (cow ’s milk, peanut, egg) and insect bite. Its clinical manifestations usually vary. They can be mild, presenting with hives, angioedema, abdominal pain; or severe, presenting with hypotension or shock, and there may be a late phase reaction. The first-line treatment for anaphylaxis is intramuscular e pinephrine. The use of anti-histamines and corticosteroids is controversial.Recent FindingsThe presence of hypotension is predictive of additional epinephrine administration.SummaryAll cases must be evaluated by an allergist. In addition to preventive measures, patients and their families need to be educated on how to manage anaphylactic reactions.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research