Tumor Deposits in Stage III Colon Cancer: Correlation With Other Histopathologic Variables, Prognostic Value, and Risk Stratification—Time to Consider “N2c”

This study analyzes the impact of tumor deposits (TDs), T and N status, poor differentiation (PD), perineural invasion (PNI), and lymphovascular invasion (LVI) on survival. Materials and Methods: A retrospective analysis (2010-2015) of the National Cancer Database of stage III colon cancer patients treated with both surgery and chemotherapy was conducted. Data was extracted on sex, race, age at diagnosis, Charlson-Deyo Score, histopathologic variables, and survival rates. Statistical analysis used the test of proportions, log-rank test for Kaplan-Meier curves, and Cox proportional hazard models. Results: For the 42,901 patients analyzed, 5-year survival rates were similar for LN+TD− (59.8%) and LN−TD+ (58.2%), but significantly worse for LN+TD+ (41.5%) (P
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

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Treatment of a variety of bowel diseases like Crohn’s disease, ulcerative colitis, colonic cancers, colonic pathologies, and systemic delivery of drugs at the target sites can be done with the help of targeted drug delivery technique. Conventional colon specific drug delivery systems lack specificity and release significant amount of drug prior reaching the target site. Hence, efficient drug delivery system that ensures effective release of the drug at the colon is still a sought after research arena. Ligand anchored therapy is a strong and effective approach to execute drug delivery in selective target cells, for bo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Cytokine-induced killer cell immunotherapy combined with first-line chemotherapy could significantly improve the OS and PFS of patients with mCRC, particularly for patients with metastatic colon cancer. PMID: 32076550 [PubMed]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Immunology Source Type: research
Abstract Drug resistance limits the efficacy of chemotherapy in human cancers. Previous studies reported that long noncoding RNA colon cancer-associated transcript 1 (CCAT1) regulated progression of prostate cancer (PCa). However, the potential role of CCAT1 in the sensitivity of paclitaxel (PTX) in PCa and its mechanism remain largely unknown. The PTX-resistant PCa cells were established in PC3 and DU145 cells by increasing concentrations of PTX. The expressions of CCAT1, microRNA-24-3p (miR-24-3p) and fascin1 (FSCN1) were measured by quantitative real-time polymerase chain reaction. The viability and apoptosis w...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
Publication date: Available online 21 February 2020Source: European Journal of Surgical OncologyAuthor(s): Pamela Minicozzi, Massimo Vicentini, Kaire Innos, Clara Castro, Marcela Guevara, Fabrizio Stracci, MaCarmen Carmona-Garcia, Miguel Rodriguez-Barranco, Katrijn Vanschoenbeek, Elisabetta Rapiti, Alexander Katalinic, Rafael Marcos-Gragera, Liesbet Van Eycken, Maria José Sánchez, Magdalena Bielska Lasota, Paolo Giorgi Rossi, Milena Sant, the European HR Working Group on colorectal cancerAbstractIntroductionFor stage III colon cancer (CC), surgery followed by chemotherapy is the main curative approach, althou...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Contributors : Stephen N Housley ; Paul Nardelli ; Dario Carrasco ; Lilya V Matyunina ; Mengnan Zhang ; John F McDonald ; Tim C CopeSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusNeurological disorders induced by chemotherapy, including pain and other debilitating sensory conditions correlate with alterations in diverse systemic, cellular, and molecular processes. Chemotherapeutic agents variously induce inflammatory responses, metabolic disorders and associated gene expression changes, all of which have the capacity to impact sensory function . Early evidence of independent effects by cancer alone ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Abstract pH-sensitive CuS@Cu2S@Au nanoparticles (NPs) are successfully prepared by sacrificing template method. The NPs are of hollow structure, which is certified by transmission electron microscopy (TEM). The CuS@Cu2S@Au NPs can be used as carriers for doxorubicin (DOX). The DOX loaded NPs exhibit pH-sensitive release of the drug, which are prospective as controllable drug delivery system. Besides, relative to the high toxicity and lethality of the free DOX, the time-dependent release of drug from the NPs is more suitable for the long-time and lasting treatment for colon cancer. The CuS@Cu2S@Au NPs with good bio...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
This study identified multiple factors associated with failure of locally advanced colon cancer (LACC) patients to receive standard of care, particularly adjuvant chemotherapy, suggesting the need to focus on improving adjuvant chemotherapy compliance in specific populations. Non-adherence to LACC standard of care is likely a major contributor to persistently high mortality rates in Kentucky.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Southern Surgical Association Article Source Type: research
This study aimed to assess the clinical features and outcomes of neutropenic enterocolitis in patients at a comprehensive cancer center. DESIGN: This is a retrospective cohort study. SETTING: The study was conducted at the University of Texas MD Anderson Cancer Center. PATIENTS: Neutropenic enterocolitis was defined by the presence of an absolute neutrophil count
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Benign Source Type: research
CONCLUSIONS: A DNA repair gene score may predict patients likely to have poor response to chemoradiation. This score may be a relevant tool to be investigated in future studies focused on chemoradiation used in the context of organ preservation. See Video Abstract at http://links.lww.com/DCR/B104. PREDICCIÓN DE RESPUESTA DEFICIENTE A LA RADIO-QUIMIOTERAPIA NEOADYUVANTE EN PACIENTES CON CÁNCER RECTAL UTILIZANDO UNA PUNTUACIÓN DE DESREGULACIÓN DE REPARACIÓN DE ADN: ESCOGER LOS PERDEDORES EN LUGAR DE LOS GANADORES ANTECEDENTES: Los pacientes con cáncer rectal pueden someterse a ...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
This study aimed to quantify and compare the risks of venous thromboembolism before surgery, after surgery, during adjuvant chemotherapy, and up to 365 days after surgery among patients with resected colon cancer. DESIGN: This is a population-based retrospective cohort study. SETTING: This study was conducted in a single-payer, universal health care setting (Ontario) between 2002 and 2008. PATIENTS: A total of 6806 patients with stage I to III colon cancer treated with surgical resection were included. INTERVENTIONS: Phases of treatment were evaluated, including preoperative, in-hospital, postoperative, during ...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Colorectal Cancer Source Type: research
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