The Innate Immune Sensor Sting Promotes Donor CD8+ T Cell Activation and Recipient APC Death Early after Preclinical Allogeneic Hematopoietic Stem Cell Transplantation

Graft-versus-host disease (GVHD) remains a significant cause of morbidity and mortality in patients receiving allogeneic hematopoietic stem cell transplants (aHSCTs). Pre-HSCT chemoradiation results in the death of dividing cells and release of endogenous danger signals. These molecules drive the activation of antigen presenting cells (APCs) and the differentiation of allo-reactive donor T cells. We identified a role for Stimulator of Interferon Genes (STING), an innate immune sensor, in GVHD using  pre-clinical MHC-matched unrelated donor (MUD) HSCT models.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Cameron S. Bader, Henry Barreras, Casey O. Lightbourn, Sabrina N. Copsel, Dietlinde Wolf, Jingjing Meng, Jeonghyun Ahn, Krishna V. Komanduri, Bruce R. Blazar, Lei Jin, Glen N. Barber, Sabita Roy, Robert B. Levy Tags: 35 Source Type: research