Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide for Severe Aplastic Anemia

Severe aplastic anemia is a life-threatening disease usually treated with immunosuppression or HSCT. This is a multicenter retrospective study that included 78 patients who have undergone haploidentical HSCT with PTCy for severe aplastic anemia in Brazil between 2010 and 2019. Median age was 14 y/o (range: 1-69), and most patients had been heavily transfused. Conditioning regimen was FluCyTBI-based, and GVHD prophylaxis consisted of PTCy, MMF, and tacrolimus (13%) or cyclosporine (87%). Most grafts (92%) were bone marrow.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Carmem Bonfim, Leonardo Javier Arcuri, Samir Nabhan, Adriana Seber, Samantha Nichele, Vaneuza Ara újo Moreira Funke, Juliana Folloni Fernandes, Liane Esteves Daudt, Luiz Guilherme Darrigo, Ana Luiza Melo Rodrigues, Renato Luiz Guerino Cunha, Celso Arrais Tags: 377 Source Type: research