Allogeneic Stem Cell Transplantation Has Limited Benefit in Older Patients with Mixed Phenotype Acute Leukemia

Mixed phenotype acute leukemia (MPAL) is a high risk leukemia that has markers of both myeloid and lymphoid lineage. The role of hematopoietic stem cell transplantation (alloHSCT) remains uncertain especially in the older population. We sought to evaluate the outcomes of our cohort of MPAL patients who were transplanted, including older adults unfit for MAC compared with the outcomes of patients who were consolidated with chemotherapy only.Methods: 74 patients aged 18 years or older, at the Princess Margaret Cancer Centre between January 1, 2000 and December 31, 2018 were evaluated.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Claire Andrews, Eshetu Atenafu, Tracy Murphy, Zeyad Al-Shaibani, Steven Chan, Vikas Gupta, Dennis D. Kim, Rajat Kumar, Wilson Lam, Jeffrey H. Lipton, Jonas Mattson, Dawn Maze, Fotios V. Michelis, Caroline McNamara, Aaron Schimmer, Andre C. Schuh, Hassan S Tags: 174 Source Type: research