Reelin reverts the main pathological processes related to Alzheimer's and other tauopathy

(University of Barcelona) Promoting the signalling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioural alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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When PET scans reveal elevated amyloid levels in cognitively normal older adults,...Read more on AuntMinnie.comRelated Reading: FDG-PET shows where exercise could stall Alzheimer's PET, MRI link amyloid plaque with swift decline Who should get brain scans for Alzheimer's disease? PET, MRI show physical activity aids brain health Would high amyloid level spur physician-assisted death?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Alzheimer Europe) Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe. The report findings show that, despite a marked reduction in the prevalence of dementia, the number of people with dementia is nonetheless set to double by 2050.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
For a variety of sporadic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, it is well-established that ethnicity do affect the disease phenotypes. However, how the ethnicity could contribute to the clinical symptoms and disease progressions in monogenetic disorders, such as spinocerebellar ataxia type 3 (SCA3), remains less studied.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Photo credit Niklas Hamann  “My mom is 81 and lives alone in her condo,” Judy Hanson writes. “Her arthritis is painful, but she gets around with a walker. Her mind is okay for now, though she is sometimes forgetful. I also feel that she is lonely. “I’m worried about her safety and have been telling her for several years that she needs help,” she continues. “I’m not proud to say that I’ve stooped to yelling at her, but I have done it. I hate the thought of her falling and not having help, and I also think she’d be happier with more company. There’s ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractPurpose of ReviewWest Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of the world. Twenty years after its introduction in the USA, it is becoming apparent that neurological impairments can persist for years following infection. Here, we review the epidemiological data in support of such long-term deficits and discuss possible mechanisms that drive these persistent manifestations.Recent FindingsFocusing on the recently discovered antimicrobial roles of amyloid and alpha-synuclein, we connect WNV late pathology to overlapping features encountered in neurodegenerative dise...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
MONDAY, Feb. 17, 2020 (American Heart Association News) -- Bleeding strokes are the deadliest type of stroke and the hardest to treat. What might make matters worse is having both diabetes and Alzheimer's disease versus either condition alone, new...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(University of South Florida (USF Health)) The proteinβ-arrestin-2 increases the accumulation of brain-damaging tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health (USF Health) Morsani College of Medicine found. The research suggests a new treatment approach that could be preventive for those at risk or with mild cognitive impairment, and also for those with Alzheimer's disease and other overt dementias caused by tau.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Alzheimer ’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Chitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer ’s disease (AD). Although studies have demonstrated that cerebrospinal fluid ...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
This article was corrected online.
Source: JAMA Neurology - Category: Neurology Source Type: research
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