Quercetin and indole-3-carbinol inhibit extracellular matrix expression in human primary uterine leiomyoma cells

ConclusionsThis study demonstrates the in vitro anti-fibrotic, anti-migratory and anti-proliferative effects of quercetin and I3C laying the scientific bases for the development of new therapeutic and/or preventive agents for the uterine leiomyomas.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Conclusions: Clear exposure of gastric SETs during MCB may improve the diagnostic rate of such examinations. PMID: 32053861 [PubMed - as supplied by publisher]
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
First step in evaluating a woman with clinical suspicion of leiomyomas is to look into typical symptoms such as heavy or prolonged menstrual bleeding, bulk related symptoms (pelvic pressure or pain, constipation, and dyspareunia) or reproductive dysfunction. Fibroids are sometimes found in asymptomatic women during routine pelvic examination or incidentally during imaging. The clinician should also perform a precise physical examination comprising of abdominal and pelvic examination. The abdominal examination should include palpation for a pelvic or abdominal mass and the uterine fundus should be noted.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
Uterine leiomyomas are the most common benign tumors of the uterus with a premenopausal cumulative clinically relevant incidence of 50% in black and 35% in white women [1]. The standard treatment for symptomatic fibroids is hysterectomy, but there has been a shift towards less invasive approaches like myomectomy, high intensity focused ultrasound and UFE [1 –3]. Mid- and long-term studies evaluating therapy effectiveness after UFE suggest freedom from treatment failure between 70%-90%, based on follow-up times between 1 and 10 years [2,3,5–9]; however, follow-up data longer than 10 years after UFE...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
Abstract Radiological guided intervention techniques are discussed in obstetric and gynecologic patients. Fallopian tube recanalization, postpartum hemorrhage control, techniques of treating uterine leiomyomas, pelvic congestion treatment, and the use of percutaneous and transvaginal ultrasonography-guided aspirations and biopsy are covered. These techniques use basic radiological interventional skills and show how they are adapted for use in the female pelvis. PMID: 32044017 [PubMed - in process]
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
Ulipristal acetate is a selective progesterone receptor modulator that acts on progesterone receptors in uterine muscle and endometrium. It is effective in reducing the size of uterine leiomyomas (fibroids) and in managing associated menorrhagia. Although ulipristal acetate–associated pathologic changes have been previously documented in the endometrium, it is unclear what morphology can be expected in posttreatment fibroids. We herein report 2 cases in which patients underwent hysterectomy, after at least two 3-mo courses of ulipristal acetate. The fibroids demonstrated some pathologic changes that have previously b...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research
Inflammatory myofibroblastic tumors (IMTs) are spindle cell neoplasms of intermediate (borderline) biologic potential with tendency for local recurrence but low risk of metastasis. They affect children more than adults. The most common sites of involvement are the lung, soft tissue, peritoneum, bladder, and less commonly the gynecologic tract. IMTs are characterized by spindle to epithelioid cells with myofibroblastic differentiation, some degree of smooth muscle differentiation, myxoid stroma and usually associated with brisk lymphoplasmacytic infiltrates. In about half of the cases, IMTs are associated with rearrangement...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Corpus: Case Reports Source Type: research
We report a rare case of tongue base leiomyoma successfully resected with transoral endoscopic surgery.A 14-year-old male was found to have a tongue base tumor. The tumor located in the right tongue base. It had a smooth surface and no deep invasion. The tumor was resected with transoral videolaryngoscopic surgery. There were no serious adverse events requiring further intervention.
Source: Auris, Nasus, Larynx - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
Radiological guided intervention techniques are discussed in obstetric and gynecologic patients. Fallopian tube recanalization, postpartum hemorrhage control, techniques of treating uterine leiomyomas, pelvic congestion treatment, and the use of percutaneous and transvaginal ultrasonography-guided aspirations and biopsy are covered. These techniques use basic radiological interventional skills and show how they are adapted for use in the female pelvis.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
ConclusionScrotal leiomyoma is a rare benign mesenchymal tumor of the middle-aged men. The current report describes the clinical and histopathological characteristics to help reduce erroneous diagnoses of this rare tumor.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
This study introduces the benefit of three-dimensional computed tomography reconstruction for preoperative prepa...
Source: BMC Medical Imaging - Category: Radiology Authors: Tags: Case report Source Type: research
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