Effectiveness and Safety of Direct Oral Anticoagulants versus Warfarin in Obese Patients with Acute Venous Thromboembolism
ConclusionTo our knowledge, this is the largest clinical study to date showing that patients with obesity can be effectively and safely treated with a DOAC compared with warfarin for acute VTE. Thus, DOACs should be considered as a reasonable alternative to warfarin for treatment of acute VTE in obese patients.
Authors: Lee YM, Park SH, Lee DH Abstract OBJECTIVE: The aim of this paper is to propose a new hypothesis for the role of lipophilic chemical mixtures stored in adipose tissue in the development of dementia. Specifically, we present how the dynamics of these chemicals can explain the unexpected findings from the Action for Health in Diabetes (Look AHEAD) study, which failed to show long-term benefits of intentional weight loss on cognition, despite substantial improvements in many known risk factors for dementia. Moreover, we discuss how the role of obesity in the risk of dementia can change depending on the dynami...
Publication date: Available online 25 February 2020Source: Evaluation and Program PlanningAuthor(s): Tanis J. Walch, Richard R. Rosenkranz, Michaela A. Schenkelberg, Bronwyn S. Fees, David A. Dzewaltowski
We thank Dr Reiffel for his interest in our case description1 and his comments. Indeed, the presence of precordial T-wave inversions in the setting of pulmonary embolism has been described periodically in the literature. The cases described by Dr Reiffel supplement the cases we referenced in our report to reinforce this point. Two theories are often cited as an explanation for this finding. The first is heightened sympathetic tone caused by an autonomic nervous system –mediated response triggered by acute pulmonary embolism.
Publication date: March 2020Source: The Lancet Haematology, Volume 7, Issue 3Author(s): Stuart L Cohen, Chinara Feizullayeva, John A McCandlish, Pina C Sanelli, Thomas McGinn, Benjamin Brenner, Alex C Spyropoulos
Publication date: Available online 25 February 2020Source: Journal of EthnopharmacologyAuthor(s): Wei Zhuang, Ge Sun, Xiaolan Lin, Bin Chen, Li Wu, Dechun Jiang, Shengyan Xi
Publication date: Available online 26 February 2020Source: Current Therapeutic ResearchAuthor(s): Hailemaryam Alemu, Workagegnehu Hailu, Aynshet Adane