Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.

CONCLUSIONS: Our data demonstrate that acute inhibition of a subset of excitatory neurons after ischemic stroke can prevent brain injury and improve functional outcome. This study, together with the previous work in optogenetic neuronal modulation during the chronic phase of stroke, supports the notion that targeting neuronal activity is a promising strategy in stroke therapy.
PMID: 31962128 [PubMed - as supplied by publisher]

Source: Experimental Neurology - January 17, 2020 Category: Neurology Authors: Wang YC, Galeffi F, Wang W, Li X, Lu L, Sheng H, Hoffmann U, Turner DA, Yang W Tags: Exp Neurol Source Type: research