Metformin Delays the Development of Atherosclerosis in Type 1 Diabetes Mellitus Via the Methylglyoxal Pathway

ConclusionsMetformin can limit the development of atherosclerosis secondary to diabetes in young diabetic mice. A possible mechanism is the removal of methylglyoxal, thereby reducing the formation of advanced glycation endproducts, rather than by lowering the blood glucose level.FundingThis work was supported by the National Natural Science Foundation of China (81901106) and Jinan clinical medical science and technology innovation plan (201907002).
Source: Diabetes Therapy - Category: Endocrinology Source Type: research