Echocardiographic tissue imaging evaluation of myocardial characteristics and function in cardiomyopathies

AbstractCurrent echocardiography techniques have allowed more precise assessment of cardiac structure and function of the several types of cardiomyopathies. Parameters derived from echocardiographic tissue imaging (ETI) —tissue Doppler, strain, strain rate, and others—are extensively used to provide a framework in the evaluation and management of cardiomyopathies. Generally, myocardial function assessed by ETI is depressed in all types of cardiomyopathies, non-ischemic dilated cardiomyopathy (DCM) in particular . In hypertrophic cardiomyopathy (HCM), ETI is useful to identify subclinical disease in family members of HCM, to differentiate HCM from other conditions causing cardiac hypertrophy and to predict cardiac events. ETI also for HCM allows addressing the mechanism behind left ventricular outflow tract obstruction and its improvement after therapeutic options. ETI provides cardiac amyloidosis with unique and specific findings such as “apical sparing.” Nevertheless, ETI does not seem to provide as much information amenable to histological findings as recently emerging techniques of cardiac mag netic resonance imaging. This review introduces usefulness of ETI and some other ultrasound techniques for detecting clinical and subclinical characteristics of cardiomyopathies, focusing on DCM, HCM, and cardiac amyloidosis.
Source: Heart Failure Reviews - Category: Cardiology Source Type: research

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We present a case report of an adult woman with AKL-positive ALCL, diagnosed by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA).A 59-year-old women with no history of breast implants, was admitted for a four-month low back pain. Initially, the patient was treated for a spondyloarthropathy, but due to persistence of the symptoms, a lumbosacral MRI was performed, showing changes in morphology and signal intensity in the vertebral body of L3, along with edema and a paravertebral collection that affected the left psoas muscle, suggesting granulomatous spondylodiscitis. Chest CT-scan showed mild left ...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP. Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Results: The intraocular pressure at 1 hour and 6 hours after PRP was significantly raised in both groups. Mean intraoc...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Acta Obstetricia et Gynecologica Scandinavica, Volume 99, Issue 3, Page 423-425, March 2020.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Tags: PATIENT PERSPECTIVE Source Type: research
Traumatic brain injury (TBI) is a leading cause of disability in the United States. With decreasing mortality rates, a higher number of patients are impacted by long-term neuropsychiatric sequelae, such as cognitive deficits, depression, anxiety, and sleep-wake disorders. These sequelae are primarily driven by the disruption of key neurotransmitter homeostasis including dopamine, norepinephrine, serotonin, and acetylcholine. Neurostimulants are centrally acting medications used to assist in restoring these neurotransmitter abnormalities and are pharmacologic options to ameliorate symptoms in post-TBI patients. Examples of ...
Source: Critical Care Nursing Quarterly - Category: Nursing Tags: Original Articles Source Type: research
Conclusion Overall cost was higher for patients with DM, whether or not they were admitted with acute HF due to HFrEF or HFpEF. Cost per day alive for patients with DM continued to exceed corresponding costs for patients without DM, with HFpEF patients with DM having the highest cost.
Source: Cardiovascular Endocrinology - Category: Cardiology Tags: Original Articles Source Type: research
ABSTRACTBACKGROUNDVEST did not demonstrate a significant reduction in arrhythmic death with the wearable cardioverter ‐defibrillator (WCD), but compliance with the device may have substantially affected the results. The influence of WCD compliance on outcomes has not yet been fully evaluated.METHODSUsing linear and pooled logistic models, we performed as ‐treated analyses omitting person‐time in the hospital and adjusted for correlates of WCD compliance. To assess the impact of early stopping of WCD, we performed a per‐protocol Kaplan‐Meier analysis, censoring after the last day the WCD was worn. Interactions of ...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Got 60 seconds? Take a mental health minute to learn about depression.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
ConclusionsThe obtained results showed that the proposed method was quite efficient in histopathological image classification. Despite the relative simplicity of the approach, the obtained results were far superior to previously reported results.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
Publication date: Available online 21 February 2020Source: NeuroscienceAuthor(s): Stefania Beretta, Laura Gritti, Chiara Verpelli, Carlo SalaAbstractTwo major processes tightly regulate protein synthesis, the initiation of mRNA translation and elongation phase that mediates the movement of ribosomes along the mRNA. The elongation phase is a high energy-consuming process, and it is mainly regulated by the eukaryotic elongation factor 2 kinase (eEF2K) activity that phosphorylates and inhibits eEF2, the only known substrate of the kinase. Several signaling pathways closely regulate the activity of eEF2K because the translatio...
Source: Neuroscience - Category: Neuroscience Source Type: research
Abstract The oxygen uptake (V˙O2) kinetics during onset of and recovery from exercise have been shown to provide valuable parameters regarding functional capacity of both chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients. To investigate the influence of comorbidity of COPD in patients with CHF with reduced ejection fraction on recovery from submaximal exercise, 9 CHF-COPD male patients and 10 age-, gender-, and left ventricle ejection fraction (LVEF)-matched CHF patients underwent constant-load exercise tests (CLET) at moderate and high loads. The V˙O2, heart rate (HR), and ca...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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