The repertoire of tumor-infiltrating lymphocytes within the microenvironment of oral squamous cell carcinoma reveals immune dysfunction

ConclusionsOur results suggest an antigen-driven immune response; however, the immune dysfunction within the microenvironment in OSCC and the Th17/Treg balance may play important roles in the modulation of antitumor immunity.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research

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ConclusionsThe results reinforce the need to develop programs and preventive actions for oral cancer in western Santa Catarina, since the cases of SCC were diagnosed in advanced stage, affecting their quality of life, and disease-free survival time.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
The treatment of malignant neoplasm of the nasal upper airway presents a high morbidity rate for patients. Radiotherapy is one therapeutic option. The patient undergoing head and neck radiotherapy treatment needs to perform a dental examination before, during, and after cancer treatment. A male African American patient, 52 years of age with a history of being a former smoker and alcoholic for 12 years, was diagnosed in 2005 with an oral squamous cell carcinoma in the left lateral lingual surface, clinical stage of T2 N0 M0, and treated with head and neck surgery with negative cervical lymph nodes.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Oral cancer is the seventh most frequent type of cancer in the Brazilian population, with high invasiveness, metastasis rates, and recurrence. The main risk factors involved are tobacco consumption, alcoholism, and human papillomavirus (HPV) infection. Oral squamous cell carcinoma (OSCC) is the most frequent histologic type. Studies report miR-181 as an important biomarker for the prognosis and survival during glioblastoma multiforme pathogenesis. However, there is no evaluation of their expression in the OSCC, nor their relation with clinical-pathologic data.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In the last decades, an increase in the incidence rates of oral squamous cell carcinoma has been reported in patients younger than 45 years.Objective: To describe clinical and demographic characteristics and risk factors in patients younger than 45 years with squamous cell carcinoma of the oral mucosa.Study Design: A total of 12 patients younger than 45 years were included in a retrospective descriptive study from 2009 to 2017. Variables registered were age, sex, tumor location, potentially malignant disorders, environmental or professional carcinogens, human papilloma virus, chronic mechanical irritation, tobacco, alcohol...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
The carcinogenesis in the oral cavity occurs as a multistep process and is often preceded by potentially malignant lesions. The main risk factors for the development of oral cancer are smoking and alcohol intake. The current challenge is to identify patients at greatest risk for the development of oral cancer using noninvasive and effective methods. The aim of this study is to evaluate the microsatellite mutations in the 9p21 locus, the cell proliferative activity, the pattern of epithelial desquamation, and the nucleus/cytoplasm ratio of exfoliated epithelial cells. Cytopathological samples were collected from 131 individ...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Oral Cancer Source Type: research
Background Traditionally oral squamous cell carcinoma (SCC) has been associated with risk factors such as smoking, alcohol and betel quid. Chronic dental trauma secondary to sharp teeth and ill-fitting dentures has also been postulated as a risk factor for oral cancer. Our study was aimed to identify if primary practitioners were recognising and treating the cause for the oral mucosal trauma in addition to referring them on to specialist care for management of the oral lesions.
Source: The British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: P45 Source Type: research
ConclusionPre-treatment panendoscopy can reveal synchronous malignancies of the upper aerodigestive tract in patients with primary oral squamous cell carcinoma. Risk stratification of patients can avoid unnecessarily conducted panendoscopy in patients without risk factors. This may lead to a higher cost-efficacy in public health system, less treatment-related complications and earlier treatment initiation.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Extratumoral perineural invasion is significantly associated with poorer locoregional control, disease ‐free survival and overall survival justifying its role as prognostic factor. AbstractPurposePerineural invasion (PNI) is an adverse prognostic factor in patients with oral cavity squamous cell carcinoma (OCSCC). The American Joint Committee on Cancer Staging Manual, eighth edition, introduced a subdivision of PNI into two distinct forms, that is, extratumoral and intratumoral PNI (EPNI and IPNI, respectively). We designed the current study to assess whether EPNI and IPNI have different prognostic implications in terms ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 12 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S.N. Rogers, A. Swain, C. Carroll, D. LoweAbstractAfter their initial presentation of oral squamous cell carcinoma (SCC), patients have a lifelong risk of developing another new SCC of the head and neck. The aim of this study was to establish second primary rates, baseline characteristics (site, clinical or pathological stage, and smoking and alcohol history), timing, presentation, treatment, and outcomes. From the regional unit we analysed records of patients treated with curative intent for their first or...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 6 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): M. Mermod, A. Adam, C. Clair, M. Faouzi, C. Simon, J.-B. Daeppen, N. Bertholet, Y. MonnierAbstractSquamous cell carcinoma (SCC) of the head and neck is the sixth most common cancer worldwide. It is preceded by early asymptomatic lesions which, if identified early enough and removed, would prevent malignant transformation or avoid delaying diagnosis to advanced stages. Our aim was to evaluate the feasibility of a screening programme for SCC of the head and neck in a group of high-risk patients, and to investi...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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