Effects of chronic hypoxia on the expression of seladin-1/Tuj1 and the number of dark neurons of hippocampu

ConclusionsIn this study, a new model of AD was developed which showed the underlying mechanisms of AD and its relations with chronic hypoxia. Hypoxia for 30 days decreased seladin-1, Tuj1 expression, increased the number of dark neurons, and also induced memory impairment. These results indicated that chronic hypoxia mediated the dementia underlying AD and AD-related pathogenesis in rat.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research