No dataset left behind: mechanistic insights into thyroid receptor signaling through transcriptomic consensome meta-analysis.

CONCLUSIONS: The mouse TR datasets and consensome are freely available in the Signaling Pathways Project website for hypothesis generation, data validation and modeling of novel mechanisms of TR regulation of gene expression. Our results demonstrate the insights into the mechanistic basis of thyroid hormone action that can arise from an ongoing commitment on the part of the research community to the deposition of discovery-scale datasets. PMID: 31910096 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research