Clinical blood gas indices and histopathological effects of intrathecal injection of tolfenamic acid and lidocaine Hcl in donkeys

In conclusion, the present study uncovered the analgesic and motor effects of commercially prepared tolfenamic acid following intrathecal injection in donkeys. Nevertheless, it is unsafe because of its neurotoxic effect on the spinal cor d which was manifested clinically by paraplegia of donkeys. On the other hand, intrathecal administration of lidocaine Hcl was safe and causes nonserious cardiopulmonary changes.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research