Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.

DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD. PMID: 31914227 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research

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Authors: Marinescu RV, Lorenzi M, Blumberg SB, Young AL, Planell-Morell P, Oxtoby NP, Eshaghi A, Yong KX, Crutch SJ, Golland P, Alexander DC Abstract We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from larger multimodal datasets from common neurodegenerative diseases. DKT is a joint-disease generative model of biomarker progressions, which exploits bio...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
Conclusions: This work has shown that accurate amyloid PET images can be generated using trained CNNs with simultaneously-acquired MR images and PET images reconstructed from actual ultra-low-dose radiotracer injections. Acknowledgements: This work was made possible by the Michael J. Fox Foundation, the Stanford Alzheimer's Disease Research Center, the NIH Grant P41-EB015891, GE Healthcare, the Foundation of the ASNR, and Life Molecular Imaging.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Artificial Intelligence for Image Enhancement/Analysis and Disease Assessment Source Type: research
Conclusions: Training data suggests that eCBF measures from dynamic florbetapir-PET studies strongly correlate with tau positivity measured with flortaucipir-PET across all subjects irrespective of amyloid status. Successful development of this approach could simplify and decrease the cost of acquiring neuroimaging biomarkers of amyloid and tau. References: Raman F, et al. (2019) Biomarker Localization, Analysis, Visualization, Extraction, and Registration (BLAzER) Methodology for Research and Clinical Brain PET Applications. J Alzheimers Dis 70, 1241-1257. **NOTES: Data used in preparation of this article were obtained fr...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Amyloid & amp; Tau PET Source Type: research
Conclusion: The study demonstrates preliminary evidence of the potential beneficial impact of gamma-induction tACS protocols in AD, also showing the utility of Tau PET tracers as [18F]-AV-1451 for the reliable detection/quantification of modification in p-Tau deposition in AD. Acknowledgements: DARPA project D17AP00080, RO1A6060981, P41EB022544
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurodegenerative Diseases Source Type: research
The objective of this study was to investigate the brain metabolic pattern for normal aging using 18F-fluorodeoxyglucose (FDG) combined positron emission tomography and magnetic resonance imaging (PET/MRI). Methods: Resting-state brain FDG PET imaging was performed in a cohort of 200 gender-matched healthy subjects across a wide age range from 20 to 70 years old. All subjects had given their informed consent and were screened clinically to exclude organic brain disease. SVD-based PCA was used to identify the aging-related metabolic brain patterns for the subjects [2]. The expression scores of principal components (PCs) wer...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
1549Objectives: Molecular imaging of tauopathies is complicated by the differing specificities and off-target binding properties of available ligands for positron-emission-tomography (PET). [18F]-APN-1607 ([18F]-PM-PBB3) is a newly developed tau tracer. The aim of the study was to characterize the imaging properties of [18F]-APN-1607 in Alzheimer’s disease (AD) patients compared to normal control (NC) subjects. Methods: We obtained PET recordings with [18F]-APN-1607 and [18F]-FDG in patients with a clinical diagnosis of AD group (N=19, 61.83±11.89 y,7 male/12 female), along with an age-matched NC group ([18F]-...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
This study presents results from a clinical case series addressing the etiology behind these observations. This study examined preliminary results collected from a pilot study of WTC responders with CI (WTC-CI), whose burden of β-amyloid (Aβ) or tau deposition and neurodegeneration in cortical regions of interest (ROI’s) was assessed to determine whether or not it followed hallmarks of Alzheimer’s disease (AD) neuropathology. Methods: Twelve WTC-CI responders with Montreal Cognitive Assessment (MoCA) score
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
This diagnostic study examines the use of RO948 F 18 in tau positron emission tomographic imaging as a diagnostic marker for identification of Alzheimer disease compared with magnetic resonance imaging and cerebrospinal fluid measures.
Source: JAMA Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons. PMID: 32384286 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Elevated plasma levels of exosomal BACE1‑AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease. Mol Med Rep. 2020 May 05;: Authors: Wang D, Wang P, Bian X, Xu S, Zhou Q, Zhang Y, Ding M, Han M, Huang L, Bi J, Jia Y, Xie Z Abstract Long non-coding RNA (lncRNA) and exosomes are involved in the pathological process of Alzheimer's disease (AD), the pathological changes of which are usually first observed in the entorhinal cortex and hippocampus. The aim of the present study was to determine whether the measurement of pla...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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