Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin α8-mediated activation of RhoA signaling pathway

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases that may progress to liver fibrosis or cancer. The present study aimed to investigate the role of microRNA-125b-5p (miR-125b-5p) in NAFLD and to further explore underlying molecular mechanisms.

Source: Metabolism - Clinical and Experimental - January 7, 2020 Category: Biomedical Science Authors: Qingxian Cai, Fengjuan Chen, Fen Xu, Ke Wang, Ka Zhang, Guojun Li, Jun Chen, Hong Deng, Qing He Source Type: research