Statin use and dementia after a concussion in older adults

There are inconsistent results on the association between statin use and the risk of dementia. Power et al. conducted a systematic review and concluded that randomized controlled trials (RCTs) and well-conducted observational studies did not support a causal preventative effect of late-life statin use on cognitive decline or dementia [1]. As concussion is a risk factor of dementia, Redelmeier et al. recently conducted a prospective study to evaluate the association between statin use and the risk of dementia after a concussion in older adults [2].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research

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In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence emission spectroscopy.SignificanceThe prediction of such binding affinity with metals on the active sites and its impact on the c...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Gluszewska A, Gryglewska B, Rewiuk K, Zarzycki B, Dzieza-Grudnik A, Kwater A, Major P, Budzynski A, Gasowski J, Grodzicki T Abstract Subclinical arterial damage connected with endothelial dysfunction is a common denominator of cardiovascular complications in a variety of metabolic diseases, including obesity. The aims of the study was to assess functional vascular changes measured by flow-mediated dilatation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery, and to measure vascular structural alterations estimated by carotid intima-media complex thickness (IMT) in short- (10 days) and medi...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
ConclusionsThere are elevated levels of risk for CVD in some athletes, primarily football players. Lifestyle behaviours associated with elite athleticism, particularly football linemen potentially expose players to greater metabolic and CVD risk, which is not completely offset by sport participation.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
There are inconsistent results on the association between statin use and the risk of dementia. Power et al. conducted a systematic review and concluded that randomized controlled trials (RCTs) and well-conducted observational studies did not support a ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Concussion in older adults is tied to a dramatically increased risk for dementia, but new research suggests statins may mitigate this risk.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
MONDAY, May 20, 2019 -- Older adults have an increased risk for dementia after concussion, which is modestly reduced among patients using a statin, according to a study published online May 20 in JAMA Neurology. Donald A. Redelmeier, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers at the University of Toronto found elderly people who received the drug after a hit to the head were 13 percent less likely to develop dementia then those who didn't.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Interview with Donald A. Redelmeier, MD, FRCPC, MSHSR, FACP, author of Association Between Statin Use and Risk of Dementia After a Concussion
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
(JAMA Network) Concussion is a common brain injury. This observational study of nearly 29,000 adults (66 and older) diagnosed with concussion examined whether statin use was associated with risk of long-term dementia after a concussion.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
This large extended population-based double cohort study tests whether statin use is associated with an increased or decreased risk of subsequent dementia after a concussion among older adults.
Source: JAMA Neurology - Category: Neurology Source Type: research
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