A third of community-dwelling elderly with intermediate and high level of Alzheimer's neuropathologic changes are not demented: A meta-analysis.
A third of community-dwelling elderly with intermediate and high level of Alzheimer's neuropathologic changes are not demented: A meta-analysis. Ageing Res Rev. 2019 Dec 30;:101002 Authors: Azarpazhooh MR, Avan A, Cipriano LE, Munoz DG, Erfanian M, Amiri A, Stranges S, Hachinski V Abstract This systematic review and meta-analysis assessed the bidirectional association between AD pathology and dementia in community-dwelling elderly populations. We searched PubMed/MEDLINE, Embase, Scopus, Web of Science, and references of the pertinent articles for community/population-based longitudinal cohorts with regular assessment of cognitive status of participants followed by postmortem neuropathology data, with no language and date restrictions, until 20 September 2019. Finally, we retrieved 18 articles with data from 17 cohorts comprising 4677 persons. Dementia was twice as likely in participants with definitive neuropathological indicator for AD compared to those without it: moderate/high Braak and Braak (BB) stages III-VI of neurofibrillary tangles (54% vs. 26% in participants with BB stages 0-II), the Consortium to Establish a Registry for AD (CERAD) moderate/frequent neuritic plaques scores (64% vs. 33% in participants with CERAD none/infrequent), and National Institute on Aging and the Reagan Institute of the Alzheimer's Association criteria intermediate/high AD probability (52% vs. 28% in participants with no/low AD probability). Accordingly, a substantial p...
Condition: Agitation in Patients With Dementia of the Alzheimer's Type Interventions: Drug: AVP-786; Drug: Placebo Sponsor: Avanir Pharmaceuticals Not yet recruiting
The antidepressant bupropion was no better than placebo in reducing apathy in nondepressed patients with Alzheimer-type dementia in a randomized controlled trial.Medscape Medical News
ConclusionCollectively these findings highlight the utility of targeted MS approaches to quantify biomarkers associated with AD that could be used for monitoring disease progression, stratifying patients for clinical trials and measuring therapeutic response.
Conclusions: These results suggest that attention to specific depressive symptom profile can improve diagnostic sensitivity and can be used to provide more individualized patient care.
Older people who have large body weight fluctuations may have an increased risk for developing dementia and Alzheimer’s, according to a study published inFrontiers in Endocrinology. Endocrinology Advisor
(University of Pittsburgh) Fifty million people worldwide are living with dementia. Alzheimer's disease, the most common form of dementia, afflicts 5.8 million Americans, and nearly two-thirds are women. Despite the staggering disparity among the sexes, researchers have yet to discover how biological factors affect this disease. The University of Pittsburgh's Bistra Iordanova believes that disease treatment is not a one-size-fits-all approach. She received an NIH award to study how sex differences contribute to cognitive impairment and dementia.
Photo credit Aris Fackenakis The truth, as they see it, is still the truth in their eyes. Delusions, hallucinations, agitation, aggression, and depression are all part of the gradual progression of psychosis of patients with Alzheimer ’s disease (AD). An average of 41% of these patients will experience these psychotic symptoms. One of the most common delusions these patients have are theft-related. An experienced caregiver offers her advice on how to deal with accusations of theft, which are common in dementia patients. Continue reading on Agingcare for more about how Alzheimer's - yes even younger-onset Alzheimer's ...
Conditions: Alzheimer Disease; Dementia Interventions: Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS.; Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver sham tDCS. Sponsors: Albert Einstein College of Medicine; MJHS Institute for Innovation in Palliative Care Not yet recruiting
Part of the increased risk among people with dementia may owe to high rates of new coronavirus infections in nursing homes. But this study suggests genetics may also be a factor.
An experimental tau inhibitor in development for Alzheimer's also has significant pharmacologic activity in bvFTD, a rare, rapidly progressive type of dementia that affects those younger than 65.Medscape Medical News