Should the definition of CKD be changed to include age-adapted GFR criteria? YES

The “graying of the globe” is a common mantra to describe the ever-growing segment of the world’s population who are considered old or elder. This phenomenon can be attributed in part to better control of chronic, noncommunicable illnesses associated with aging, such as cancer or cardiovascular di sease. However, despite the aging of society as a whole, the definition of chronic kidney disease (CKD), which disproportionately affects elders, has not been altered for almost 2 decades. It still uses the same absolute, non–age-adapted threshold of glomerular filtration rate (GFR), most often es timated from serum creatinine (eGFR), for defining the existence of CKD in the absence of other biomarkers of kidney injury (such as proteinuria, abnormal imaging, or renal pathologic findings).

Source: Kidney International - December 31, 2019 Category: Urology & Nephrology Authors: Richard J. Glassock, Pierre Delanaye, Andrew D. Rule Tags: Controversies in Nephrology Source Type: research