Design, synthesis and biological evaluation of 4-amino substituted 2H-chromen-2-one derivatives as an NEDD8 activating enzyme inhibitor in pancreatic cancer cells.
CONCLUSION: Based on these results, we found that compound 21 inhibited NAE activity in an ATP-dependent manner in enzyme-based system, induced apoptosis in BxPC-3 cells and synergized with bortezomib on BxPC-3 cell growth inhibition. Additionally, it had low toxicity with reasonable Log P value and water solubility.
PMID: 31880252 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - Category: Chemistry Authors: Zhu L, Lu P, Gong L, Lu C, Li M, Wang Y Tags: Med Chem Source Type: research
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