What is aldosterone escape?

What is aldosterone escape? Brief Review Abstract: The term aldosterone escape in primary hyperaldosteronism is escape from the salt and water retaining effects of aldosterone. In the treatment of heart failure with angiotensin converting enzyme inhibitors, it is the breakthrough occurrence of aldosterone effect. Different types of aldosterone escape The term ‘aldosterone escape’ has been used in two different settings: Aldosterone escape in primary hyperaldosteronism Aldosterone escape in the treatment of heart failure with angiotensin converting enzyme inhibitors Aldosterone escape in primary hyperaldosteronism Aldosterone escape in primary hyperaldosteronism is the escape from the salt and water retaining effect of excessive levels of aldosterone.1 This phenomenon is considered to be an important homeostatic mechanism and thought to be dependent on nitric oxide.2 Natriuresis produced by elevated levels of atrial natriuretic peptides is another proposed mechanism for escape from the salt retention in this situation.3 Pressure natriuresis is another proposed mechanism for aldosterone escape, with increased renal arterial pressure induced natriuresis.4 Aldosterone escape in the setting of primary hyperaldosteronism may have an important role in reducing the severity of hypertension in the condition. Aldosterone escape is the reason for edema not being a prominent manifestation of primary hyperaldosteronism. This mechanism of aldosterone escape does not work ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs