The need to incorporate aged animals into the preclinical modeling of neurological conditions

Publication date: Available online 23 December 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Mujun Sun, Stuart J. McDonald, Rhys D. Brady, Lyndsey Collins-Praino, Glenn R. Yamakawa, Mastura Monif, Terence J. O’Brien, Geoff Cloud, Christopher G. Sobey, Richelle Mychasiuk, David J. Loane, Sandy R. ShultzAbstractNeurological conditions such as traumatic brain injury, stroke, Parkinson’s disease, epilepsy, multiple sclerosis, and Alzheimer’s disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal models do not translate to patients. Many patients with these conditions are middle-aged or older, however, the majority of preclinical studies have used only young-adult animals. Considering that aging involves biological changes that are relevant to the pathobiology of neurological diseases, the lack of aged subjects in preclinical research could contribute to translational failures. This paper details how aging affects biological processes involved in neurological conditions, and reviews aging research in the context of traumatic brain injury, stroke, Parkinson’s disease, epilepsy, multiple sclerosis, and Alzheimer’s disease. We conclude that aging is an important, but often overlooked, factor that influences biology and outcomes in neurological conditions, and prov...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Health Care Slider Speech-Language Pathology Dysphagia Swallowing Disorders Source Type: blogs
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Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
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Source: Journal of Medical Systems - Category: Information Technology Source Type: research
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Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Uncategorized Source Type: blogs
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Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
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