A Large Cohort of RAG1/2-Deficient SCID Patients —Clinical, Immunological, and Prognostic Analysis

ConclusionsConsanguineous marriages account for a genetic “founder effect.” SCID is a pediatric emergency that dictates immediate precautions and curative treatment with HSCT. Due to lack of newborn screening for SCID within the Palestinian population, most patients in this cohort were diagnosed upon clinical symptoms, which led to a delayed diagnosis, harmful administration of contra-indicated live vaccines, delay in HSCT, and poor outcome.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research