Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.

In conclusion, clinical characteristics of vitamin B12 deficiency are broad and nonspecific and may not be associated with anemia and increased mean corpuscular volume. Since different clinical characteristics can be seen without anemia, awareness and cautious approach are essential in order to avoid severe clinical disease, especially in children from underdeveloped countries. PMID: 31819326 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research

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Conclusions: Antioxidants that are not specifically targeted to mitochondria fail to accumulate in significant amounts in critical sites of mitochondrial ROS production and may eventually interfere with the ensuing physiological signaling. Mitochondria-targeted antioxidants are more effective, but are expected to interfere with the mitochondrial ROS-dependent physiologic signaling. AA promotes multiple beneficial effects in mitochondria. The complex regulation of vitamin C uptake in these organelles likely contributes to its versatile antioxidant response, thereby providing a central role to the vitamin for adequate contro...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Publication date: Available online 25 January 2020Source: Revista Clínica Española (English Edition)Author(s): M. Quintana-Díaz, E.M. Andrés-Esteban, J. Sánchez-Serrano, A. Martínez-Virto, R. Juárez-Vela, J.A. García-ErceAbstractIncreasing haemoglobin and haematocrit levels with blood transfusions has been the gold standard for treating severe anaemia; however, the indication for transfusing concentrated red blood cells is based merely on a few laboratory markers, such as haemoglobin and haematocrit levels, rather than based on the symptoms according to clinical pract...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
DiscussionAlthough Retendo® (mucopolygen complex) is commonly used in muscle and tendon diseases, its effect mechanism is not definitely known. But in the light of the findings we acquired in our study, we detected that Retendo® (mucopolygen complex) applied after achilles tendon ruptures positively effected collagen sequencing during recovery in histological terms but didn't have a significant effect on the mean load achilles tendon can tolerate before rupturing.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
Authors: Renck AC, Trarbach EB, Frade Costa EM PMID: 31976827 [PubMed - as supplied by publisher]
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
AbstractThrombotic thrombocytopenic purpura (TTP) is an uncommon yet life-threatening condition, usually marked by a classic pentad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, acute kidney injury (AKI), neurological disturbances, and fevers. Prompt recognition and treatment is essential to reduce morbidity and mortality. The rarity and variability of presentations, however, makes this a difficult diagnosis to make reliably, and in many cases, treatment is initiated empirically before the appropriate diagnostic testing is completed. After TTP and other common causes of thrombotic microangiopathy (TMA) hav...
Source: Journal of Hematopathology - Category: Pathology Source Type: research
In a recent article (Perspectives in Biology and Medicine 2015,58:419-43), physician and medical historian John G. Sotos suggests that former first lady Mary Todd Lincoln suffered from pernicious anemia. In the years following her husband ’s assassination, Mrs Lincoln was noted to become socially isolated and mentally unstable. Those around her labeled her has hypochondriacal. Dr Sotos goes on to describe how the former first lady manifested a number of signs and symptoms over 3 decades that “…included sore mouth, pallor, pares thesias, the Lhermitte symptom, fever, headaches, fatigue, resting tachycardi...
Source: Medical Clinics of North America - Category: Primary Care Authors: Tags: Foreword Source Type: research
Authors: Mrabet S, Ellouze F, Ellini S, Mrad MF Abstract Biermer disease or pernicious anemia is an autoimmune atrophic gastritis characterized by the lack of secretion of gastric intrinsic factor. This leads to an insufficient absorption of vitamin B12 in the ileum. Clinical manifestations are mainly hematologic. Neuropsychiatric manifestations are known but are less frequent especially early in the disease. Inaugural neuropsychiatric arrays are rare and various thus making diagnosis difficult. In this article, we report through two clinical cases different neuropsychiatric manifestations revealing pernicious anem...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
A 39 year old female presented to a District General Hospital with fatigue, light-headedness and shortness of breath. Investigations revealed an iron deficient anaemia, initially presumed due to poor diet. Clinical examination revealed a moderate cerebellar ataxia and spastic paraparesis. Investigations included normal MRI of Whole Spine and Vitamin B12 level. MRI Brain revealed abnormal T2 and FLAIR high signal within the superior aspect of the corticospinal tracks bilaterally. Further investigation revealed low serum copper of 0.6 mcgmol/L (12.6–26.7), low serum caeruloplasmin of 0.05 g/L (0.16–0.45) and...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Brain stem / cerebellum Thur 21, Parallel session 5: Therapeutics Source Type: research
I want to take this issue head on, since popular “wisdom” is that problems with consumption of wheat and related grains begin and end with celiac disease. The Wheat Lobby, for instance, frequently argues that, if you do not have celiac disease, you have no business avoiding wheat and related grains. Defenders of wheat, such as those cited in this New York Times article, argue that celiac disease affects 1% of the human population, but that the other 99% of people not only can consume wheat with impunity, but can actually do so and obtain health benefits due to fiber and B vitamin content. They say that eliminat...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle ataxia autoimmune diabetes gluten grains Inflammation iron neuropathy skin rash Source Type: blogs
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