The Role of Vitamin K in Vascular Calcification

Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Mario Cozzolino, Maria Fusaro, Paola Ciceri, Lorenzo Gasperoni, Giuseppe CiancioloVascular calcification (VC) is common in advanced chronic kidney disease (CKD), contributes to cardiovascular disease (CVD), and associates with increased mortality. Major risk factors for VC in CKD are increasing age, dialysis vintage, and positive net calcium-phosphate balance. To date, no specific therapy that prevents progression or facilitates regression of VC beyond careful attention to calcium and phosphate balance exists. Accumulating evidence demonstrates that CKD patients may incur subclinical vitamin K deficiency. This deficiency may be induced by exhaustion of vitamin K due to its high requirement by vitamin K-dependent proteins to inhibit VC. This review analyzes the pathophysiological mechanisms and clinical consequences of vitamin K deficiency with emphasis on its involvement on vascular calcification in CKD and end-stage renal disease and its relationship to the bone-vascular axis.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research

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We present and discuss the available evidence from basic science and clinical studies, and highlight perspectives for further research.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
We present and discuss the available evidence from basic science and clinical studies, and highlight perspectives for further research. PMID: 31836502 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
You're reading The Starting Five: Vitamins for Improved Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. “By the proper intakes of vitamins and other nutrients…you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years,” said Nobel Prize winning scientist Linus Pauling. Modern research has confirmed Pauling’s belief as it has identified five vitamins that may improve overall health. Vitamin D Vitamin D provides many important health benefits. It ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness pickthebrain self improvement vitamins what vitamins should i take Source Type: blogs
This study was conducted to explore the correlations of plasma dp-ucMGP with vascular calcification and vascular stiffness in chronic kidney disease (CKD) patients.Methods: This cross-sectional study enrolled 83 CKD stages 3-5 patients. Vascular calcification score was determined by calcific lesions in the abdominal aorta (AAC) shown by lateral lumbar film; vascular stiffness was assessed by cardio-ankle vascular index (CAVI) and pulse wave velocity, while plasma dp-ucMGP levels were measured using ELISA method. Multivariate regression analyses were used to select factors that were independently associated with vascular ca...
Source: Nephron - Category: Urology & Nephrology Source Type: research
CONCLUSION: Taken together, these findings suggest that CKD impacts vitamin K metabolism, and this occurs early in the disease course. Our findings that vitamin K metabolism is altered in the presence of CKD provides further support that sub-clinical vitamin K deficiency may represent a modifiable risk factor for vascular and bone health in this population. PMID: 27846632 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Conclusion: Taken together, these findings suggest that CKD impacts vitamin K metabolism, and this occurs early in the disease course. Our findings that vitamin K metabolism is altered in the presence of CKD provides further support that sub-clinical vitamin K deficiency may represent a modifiable risk factor for vascular and bone health in this population.Am J Nephrol 2017;45:4-13
Source: American Journal of Nephrology - Category: Neurology Source Type: research
PMID: 27842304 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Am J Nephrol 2017;45:1-3
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation. To substantiate these epidemiological findings, we undertook a pilot study, in which we stained renal ti...
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
Conclusions (1) Functional vitamin K1 deficiency is explained by low vitamin K1 intake in less than half of HD patients. (2) Undercarboxylated matrix Gla protein level is a poor surrogate for functional vitamin K1 deficiency.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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