SGLT2 Inhibition Increases Serum Copeptin in Young Adults with Type 1 Diabetes.

CONCLUSIONS: - Elevated serum copeptin was associated with worse glycaemic control and lower diuresis and natriuresis. SGLT2i increased serum copeptin in adults with T1D, and the rise correlated with change in diuresis, but not natriuresis and hemo-concentration. Further work is required to evaluate the clinical implications of elevated copeptin with SGLT2i, including whether it is simply a marker of diuresis or may contribute to cardiorenal disease long-term.
PMID: 31816431 [PubMed - as supplied by publisher]

Source: Diabetes and Metabolism - December 5, 2019 Category: Endocrinology Authors: Lytvyn Y, Bjornstad P, Katz A, Singh SK, Godoy LC, Chung LT, Vinovskis CL, Pyle L, Roussel R, Perkins BA, Cherney D Tags: Diabetes Metab Source Type: research