Increased expression of FGF ‐21 negatively affects bone homeostasis in dystrophin/utrophin double knock‐out mice

In conclusion, this study demonstrates that dystrophic skeletal muscles express and secrete significant levels of FGF‐21, which negatively regulates bone homeostasis and represents an important patho logical factor for the development of bone abnormalities in DMD. The current study highlights the importance of muscle/bone cross talk via muscle derived factors (myokines) in the pathogenesis of bone abnormalities in DMD.This article is protected by copyright. All rights reserved.

Source: Journal of Bone and Mineral Research - December 3, 2019 Category: Orthopaedics Authors: Hongshuai Li, Hui Sun, Baoli Qian, Wei Feng, Dwayne Carney, Jennifer Miller, MaCalus V. Hogan, Ling Wang Tags: Original Article Source Type: research