Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signalling.

Conclusions: ENG promotes the normal balance of VEGF signalling in quiescent ECs to maintain vessel calibre, an essential function in conditions of increased VEGF expression such as local hypoxia or inflammation. In the absence of endothelial ENG increased sensitivity to VEGF drives abnormal endothelial proliferation in local regions of high VEGF expression, leading to AVM formation and a rapid injurious impact on heart function.
PMID: 31805812 [PubMed - as supplied by publisher]

Source: Circulation Research - December 5, 2019 Category: Cardiology Authors: Tual-Chalot S, Garcia-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM Tags: Circ Res Source Type: research