Hybrid MII-organic-diphosphate hydrates (MII = Mn, Ni and Zn): Structural characterization, hirshfeld surface analysis and antitumoral activity

Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Intissar Moghdad, Aicha Mbarek, Ferdinando Costantino, Sabrina Nazzareni, Houcine NaïliAbstractThree inorganic-organic hybrid diphosphates, templated by transition metal (2,6-(CH3)2C6H3NH3)2[MII(H2P2O7)2(H2O)2] (MII = Mn, Ni, Zn), were successfully synthesized by low speed of evaporation conditions after using the ion exchange chemical procedure. Their crystal structures were solved from single-crystal X-ray diffraction data. All compounds are isotypic and crystallize in the triclinic system with space group Pī. The crystal structure is built from the alternatively arranged inorganic [MII(H2P2O7)2(H2O)2]2- anions and organic [(CH3)2C6H3NH3]+ cations, stabilized by O–H⋯O and N–H⋯O hydrogen bonds and π···π stacking. The complexes were investigated by using such techniques: IR, TGA/DTA, UV–visible characterization techniques (Ni(II), Mn(II) compounds) and 1H, 13C, 31P NMR (Zn(II) compound). Hirshfeld surface analyses of the studied salts were also carried out. Finally, in vitro anticancer activities of compounds were further determined with reference to three human cancer cell lines (Human cervical (A431), pancreatic (PSN1) and human ovarian cell lines (2008)). Hybrid complexes, based on manganese, nickel and zinc, displayed in vitro efficient antitumor activity compared with the positive reference drug cisplatin.Gra...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research

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Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
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Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
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Source: Health and Place - Category: Environmental Health Authors: Tags: Health Place Source Type: research
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Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
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Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
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