Design, methodology and baseline characteristics of the Women's ischemia syndrome evaluation coronary vascular dysfunction (WISE-CVD)

Publication date: Available online 5 December 2019Source: American Heart JournalAuthor(s): Odayme Quesada, Ahmed AlBadri, Janet Wei, Chrisandra Shufelt, Puja K. Mehta, Jenna Maughan, Nissi Suppogu, Haider Aldiwani, Galen Cook-Wiens, Michael D. Nelson, Behzad Sharif, Eileen M. Handberg, David R. Anderson, John Petersen, Daniel S. Berman, Louise E.J. Thomson, Carl J. Pepine, C. Noel Bairey MerzBackgroundA significant number of women with signs and symptoms of ischemia with no obstructive coronary artery disease (INOCA) have coronary vascular dysfunction, detected by invasive coronary reactivity testing (CRT). However, the noninvasive assessment of coronary vascular dysfunction has been limited.MethodsThe Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction (WISE-CVD) was a prospective study of women with suspected INOCA, aimed to investigate whether: 1) cardiac magnetic resonance imaging (CMRI) abnormalities in left ventricular morphology and function and myocardial perfusion predicted CRT measured coronary microvascular dysfunction; 2) these persistent CMRI abnormalities at 1-year follow-up predict persistent symptoms of ischemia; and 3) these CMRI abnormalities predict cardiovascular outcomes. By design a sample size of 375 women undergoing clinically indicated invasive coronary angiography for suspected INOCA was projected to complete baseline CMRI, a priori subgroup of 200 clinically indicated CRT, and a priori subgroup of 200 repeat 1-year follow-up CMRI.Re...
Source: American Heart Journal - Category: Cardiology Source Type: research

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Publication date: February 2020Source: American Heart Journal, Volume 220Author(s): Odayme Quesada, Ahmed AlBadri, Janet Wei, Chrisandra Shufelt, Puja K. Mehta, Jenna Maughan, Nissi Suppogu, Haider Aldiwani, Galen Cook-Wiens, Michael D. Nelson, Behzad Sharif, Eileen M. Handberg, R. David Anderson, John Petersen, Daniel S. Berman, Louise E.J. Thomson, Carl J. Pepine, C. Noel Bairey MerzBackgroundA significant number of women with signs and symptoms of ischemia with no obstructive coronary artery disease (INOCA) have coronary vascular dysfunction detected by invasive coronary reactivity testing (CRT). However, the noninvasiv...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 16 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Kavit Shah, Ashutosh P. JadhavAbstractA 63 year-old female with a recent history of symptomatic left internal carotid artery stenosis (ICA) status post left ICA stenting, and known asymptomatic right ICA stenosis presented with vision loss in the right eye. CT angiogram (CTA) demonstrated mild focal in-stent stenosis of the left ICA and magnetic resonance imaging (MRI) arterial spin labeling (ASL) sequencing demonstrated decreased blood flow in the left cerebral hemisphere.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
We report a 75-year-old woman referred for non-ST-elevation myocardial infarction due to prominent Thebesian veins who displayed a perfusion defect in cardiac magnetic resonance imaging.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: August 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 8Author(s): Beatriz Saldanha Santos, Maria João FerreiraAbstractNon-invasive assessment of ischemic heart disease remains a challenging task, even with a large armory of diagnostic modalities. Positron emission tomography (PET) is an advanced radionuclide technique that has been available for decades. Originally used as a research tool that contributed to advances in the understanding of cardiovascular pathophysiology, it is now becoming established in clinical practice and is increasingly used in the diagnosis...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Abstract Numerous recent technological advances offer the potential to substantially enhance the MRI evaluation of moyamoya disease (MMD). These include high-resolution volumetric imaging, high-resolution vessel wall characterization, improved cerebral angiographic and perfusion techniques, high-field imaging, fast scanning methods, and artificial intelligence. This review discusses the current state-of-the-art MRI applications in these realms, emphasizing key imaging findings, clinical utility, and areas that will benefit from further investigation. Although these techniques may apply to imaging of a wide array o...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
CONCLUSIONS: According to the results of postoperative DW-MRI, retrograde perfusion itself might not increase the incidence of postoperative cerebral embolism in properly selected cardiac surgery patients undergoing routine preoperative CTA examination. PMID: 31776305 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
Abstract The new '2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes' emphasize the role of non-invasive functional imaging of myocardial ischemia in diagnosing coronary artery disease to guide decision regarding revascularization. Cardiac magnetic resonance (CMR) stands out relative to other imaging modalities given its high safety profile, absence of ionizing radiation and its versatility in encoding various image contrasts. CMR allows to assess myocardial function, ischemia, viability and permits tissue characterization including detection of edema in a single examination. In rec...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Authors: Kim MS, Kim GS Abstract Objective: The purpose of this study was to suggest that computed tomography angiography (CTA) is valuable as the only preliminary examination for mechanical thrombectomy (MT). MT after single examination of CTA including non-contrast computed tomography (NCCT) and maximum intensity projection (MIP) improves door-to-puncture time as well as results in favorable outcomes. Methods: A total of 157 patients who underwent MT at Dong Kang Medical Center from April 2015 to March 2019 were divided into two groups based on the examination performed prior to MT : CTA group who underwent C...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Contrast-enhanced ultrasound (CEUS) is an evolving diagnostic alternative to contrast-enhanced computed tomography, magnetic resonance imaging, and fluorescence angiography for the evaluation of vascular diseases. Microbubble contrast material allows imaging of blood flow in microvasculature beyond the resolution of standard imaging techniques and demonstrates potential for the evaluation of tissue perfusion. Several authors have investigated the application of CEUS in the evaluation of myocardial or skeletal muscle perfusion and tumor characterization.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Publication date: Available online 4 October 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Mateja de Leonni Stanonik, Christopher Sy, Cameron McDougall, Lee Birnbaum, Justin MascitelliAbstractA 59-year-old male presented with a severe left middle cerebral artery (MCA) syndrome, a National Institutes of Health Stroke Scale (NIHSS) of 17, and was last known well 26 hours prior. Computed tomography angiography (CTA) of the head demonstrated a tandem extracranial ICA and intracranial ICA/MCA occlusion. Computed tomography perfusion (CTP) demonstrated a large mismatch. The patient underwent a mechanical thrombectomy usin...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
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