Biological effects of verbascoside and its anti-inflammatory activity on oral mucositis: a review of the literature

Oral mucositis is among the most common tissue toxicities associated with both cytotoxic cancer regimens and head and neck radiotherapy. Current management of oral mucositis might comprise growth factors and cytokines, anti-inflammatory agents, anesthetics, analgesics, antimicrobial and coating agents, cryotherapy and mucosal protectants. Despite its long history and its impact on patients, there are currently no effective options for the prevention or treatment of mucositis. In recent years, more attention has been focused on the role of natural drugs. Verbascoside belongs to the phenylpropanoid glycosides family. Several biological properties have been described, such as anti-inflammatory, antimicrobial, antitumor and antioxidant. Verbascoside, particularly when in solution with polyvinylpyrrolidone and sodium hyaluronate, thanks to barrier effect, is useful in re-epithelialization and in reducing pain, oral mucositis score, burning and erythema.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Article Source Type: research

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ConclusionsIn HNC patients, oral status and taste change occurs throughout the cancer trajectory and represent potential concerns in cancer survivorship. Taste change (as evaluated by taste testing) occurred in all HNC patients, whereas olfactory changes occurred in 30% of cases. Management of oral changes and symptoms should be considered in all HNC patients in addition to dietary and nutritional guidance in patient care to promote oral intake. Continuing study of taste changes may further define this problem and support dietary and nutritional guidance and product development.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
AbstractObjectiveTo evaluate the occurrence and severity of oral complications, number of radiotherapy (RT) interruptions and quality of life (QoL) in a population of head and neck cancer patients receiving a preventive oral care program (POCP) and photobiomodulation therapy (PBMT).MethodsProspective cohort of 61 head and neck cancer patients undergoing radiochemotherapy were monitored and submitted to a POCP that included oral hygiene and plaque control, removal of infection foci, dental restorations, periodontal therapy, fluorotherapy, oral hydration, and denture removal at night, combined with daily PBMT. Outcomes inclu...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsThe correlation of MIF with the severity of OM is compatible with the role of MIF as a proinflammatory protein. This seems to be the first study to describe this association; therefore, future prospective studies would be ideal to observe pre- and post-RT alterations in salivary MIF levels to validate this result and better understand the role of MIF in the pathogenesis of OM.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
We present the first case series of performing SPG blocks utilizing TX360 nasal atomizers or angiocatheters to treat head and neck cancer–related pain. Pain scores were reduced by 38% to 80% with an average pain relief duration of 23 days.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research
Conclusion: This study will provide evidence to help determine whether Chinese herbal medicine is effective and safe for use in the prevention and/or treatment of radiotherapy induced OM. Ethics and dissemination: No additional formal ethical recognition or informed consent is required since no primary data collection is involved. The study result will be published in peer-reviewed journals or at related conferences. PROSPERO registration number: PROSPERO CRD42019141900.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
ConclusionsThe effects of the two stretching devices did not differ significantly in our study population. The factors described, influencing the progression of stretching exercises, need to be taken into account when prescribing a similar stretching regimen for trismus in head and neck cancer patients.Trial registrationNTR - Dutch Trial Register number: 5589
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 November 2019Source: Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyAuthor(s): Yukio Watabe, Yusuke Matsuzaki, Shiro ShigematsuAbstractTrismus can have intra- and extra-articular causes. Extra-articular trismus can be caused by head and neck cancers and associated treatments, oral submucous fibrous, odontogenic infection, trauma and so on. However, scar contracture due to major recurrent aphthous stomatitis (RAS) has not been reported previously as a cause of trismus. We performed Z-plasty for surgical treatment of severe trismus caused by acquired scar contracture f...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
SummaryRadiation-induced oral mucositis has a dismal outcome with limited treatment options. We conducted a phase I study to evaluate the safety and preliminary efficacy of epigallocatechin-3-gallate (EGCG) mouthwash when given along with radiation in head and neck cancer. Patients with pathologically confirmed head and neck cancer were eligible for this study. EGCG mouthwash was administered at the assigned dosage level (starting at 440  μmol/L, three times a day) in a standard 3 + 3 dose escalation design. Mucosal toxicity, patient satisfaction, and mucositis-related pain (MTP) were assessed weekly....
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe integrated clinical safety data indicated that RM-1929 PIT treatment had a favorable safety profile with no unexpected safety concerns.Clinical trial identificationNCT02422979.Legal entity responsible for the studyRakuten Medical, Inc.FundingRakuten Medical, Inc.DisclosureJ.M. Johnson: Advisory / Consultancy: Foundation Medicine; Research grant / Funding (institution): BMS; Research grant / Funding (institution): Merck; Research grant / Funding (institution): AstraZeneca. J.M. Curry: Research grant / Funding (institution): AstraZeneca. S.T. Kochuparambil: Shareholder / Stockholder / Stock options, Full / Par...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Enhanced recovery after surgery (ERAS), or fast-track surgery, was described almost 20  years ago as a peri- and postoperative care concept with the aim of achieving a pain- and risk-free operation.1 Postoperative recovery has been improved by shortening the hospital stay and reducing medical complications without increasing the risk of surgery-related complications and readmissions. 1 It has been well established that enhanced recovery programs (ERPs) can be superior to conventional care for a wide range of surgical procedures, including microsurgical reconstructive procedures, with substantial economic benefits.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Perspective Source Type: research
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