MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis

Publication date: Available online 5 December 2019Source: Neuroscience LettersAuthor(s): Md Razib Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, Tuba M. Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto, Tohru YamamotoAbstractMDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor) has recently been linked to schizophrenia and bipolar disorder. Dysregulation of dopamine (DA) and serotonin (5-HT) systems has long been associated with schizophrenia and other neuropsychiatric disorders. Here, we measured prepulse inhibition (PPI) of the startle response and ex vivo tissue content of monoamines and their metabolites in the frontal cortex, striatum and hippocampus of Mdga1 homozygous (Mdga1-KO), Mdga1 heterozygous (Mdga1-HT) and wild-type (WT) male mice. We found that Mdga1-KO mice exhibited statistically significant impairment of PPI, and had higher levels of homovanillic acid (HVA) in all three brain regions studied compared with Mdga1-HT and WT mice (P 
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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INTRODUCTION: Schizophrenia, bipolar disorder and schizoaffective disorders are severe mental illnesses (SMI) associated with high levels of co-morbid psychopathology and premature mortality. Reducing delays in accessing services and providing early interv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Renuka S. Managuli, Julie Tzu-Wen Wang, Farid Muhammad Faruqu, Abhjieet Pandey, Sanyog Jain, Khuloud T. Al-Jamal, Srinivas MutalikAbstractAsenapine maleate (ASPM) is an antipsychotic drug prescribed for the treatment of schizophrenia and bipolar disorder. ASPM possesses low oral bioavailability due to extensive hepatic metabolism. Therefore, RGD peptide conjugated liposomes loaded with ASPM were prepared to target Peyer's patches in the intestine which in-turn get access into intestinal lymphatic system thereby increasing the ora...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
ConclusionPsychotropic medication non-adherence was high. It was influenced by various factors operating at different levels. Therefore, comprehensive intervention strategies should be designed to address factors associated with psychotropic medication non-adherence.Systematic review registrationPROSPERO CRD42017067436
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Astudy appearing today inJAMA Psychiatry found that fewer than 7% of patients with psychiatric disorders in Sweden had either been subjected to violence severe enough to require specialist medical treatment or had perpetrated violence.Amir Sariaslan, Ph.D., of the University of Oxford and colleagues identified 250,419 individuals from Sweden ’s National Patient Register who were born between 1973 and 1993 and had been diagnosed psychiatric disorders. Psychiatric disorders included anxiety disorders, depression, bipolar disorder, schizophrenia, personality disorders, alcohol use disorder, and drug use disorder. The pa...
Source: Psychiatr News - Category: Psychiatry Tags: Amir Sariaslan anxiety bipolar disorder depression JAMA Psychiatry Paul Appelbaum personality disorders schizophrenia substance use disorder violence Source Type: research
DiscussionCACNA1C rs11615998 was associated with psychotic symptoms (C-allele carriers have decreased psychotic-risk) independently from the diagnosis, in line with the evidence of a cross disorder effect of many risk variants. This gene was previously associated with SCZ and cross-disorder liability to psychiatric disorders. Our findings confirmed that deep phenotyping is pivotal to clarify the role of genetic variants on symptoms patterns.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 13 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Indrani Poddar, Patrick M. Callahan, Caterina M. Hernandez, Anilkumar Pillai, Xiangkun Yang, Michael G. Bartlett, Alvin V. TerryAbstractAntipsychotic drugs (APDs) are essential for the treatment of schizophrenia and other neuropsychiatric illnesses such as bipolar disease. However, they are also extensively prescribed off-label for many other conditions, a practice that is controversial given their potential for long-term side effects. There is clinical and preclinical evidence that chronic treatment with some APDs ma...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 13 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Elisa C. Santa Cruz, Katherine C. Madrid, Marco A.Z. Arruda, Alessandra SussuliniAbstractBackgroundImbalances in metal concentrations have been suggested to contribute to the pathophysiology of different brain disorders, such as bipolar disorder (BD) and schizophrenia (SCZ).ObjectivesThe aim of this exploratory study is to evaluate the association between the concentrations of macro/trace elements in serum from BD and SCZ patients considering the effects from different treatments.MethodsEleven subjects with...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
  Sex addict. Nympho. You’ve likely heard these words used for a person with hypersexuality, but what exactly is this condition? Is hypersexuality really a symptom of a mental disorder or is it just a super high libido? Where does one draw the line between liking (or loving) sex and being hypersexual? Is it similar to a drug addiction? Or a binge eating disorder?  Join Gabe and Jackie as they tackle this often misunderstood topic and hear Gabe’s own personal experiences with hypersexuality as a debilitating symptom of his bipolar disorder. (Transcript Available Below) SUBSCRIBE &REVIEW About Th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Not Crazy Podcast Relationships Sexuality Source Type: blogs
Abstract Antipsychotics are used for many psychiatric conditions in youth. Although developmentally inappropriate weight gain and metabolic abnormalities, which are risk factors for premature cardiovascular mortality, are especially frequent in youth, optimal strategies to reduce pediatric antipsychotic-induced overweight/obesity are unclear. The Improving Metabolic Parameters in Antipsychotic Child Treatment (IMPACT) was a randomized, parallel group, 24-week clinical trial which enrolled overweight/obese, psychiatrically stable youth, aged 8-19 years, with a DSM-IV diagnosis of severe mental illness (schizop...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
CONCLUSION: Significant changes in NO, SDMA, ADMA, and L-arginine levels in schizophrenia and bipolar disorder patients suggest that NO and inhibitors of NO might be implicated in the neurobiology of schizophrenia and bipolar disorder. PMID: 31915793 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
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