Observational study of the efficacy of prolonged-release metformin in people with prediabetes.

Observational study of the efficacy of prolonged-release metformin in people with prediabetes. Curr Med Res Opin. 2019 Dec 03;:1 Authors: Hostalek U, Zilahi Z Abstract Objectives: Prediabetes is characterised by elevation of indices of blood glucose that is insufficient to provoke a diagnosis of type 2 diabetes, but markedly increases the risk of developing type 2 diabetes in the future. Lifestyle interventions are the main therapeutic intervention for the management of prediabetes. Current guidelines also support treatment of prediabetes with metformin for selected subgroups of patients, and metformin has a therapeutic indication for this use in a number of countries.Methods: We performed an observational, non-interventional study of the effects on glycaemia of prolonged-release metformin (Glucophage XR, referred to henceforth as metformin XR) in 686 subjects with prediabetes. Metformin was prescribed according to physicians' usual care practices, and the study duration was 12 weeks.Results: Mean (SD) fasting plasma glucose (FPG) at baseline was 6.2 (0.4) mmol/L [111 (8) mg/dL) and was reduced by -0.55 (0.7) mmol/L [-10 (13) mg/dL] after 12 weeks of metformin XR. FPG was normalised to below the American Diabetes Association cut-off for the diagnosis of prediabetes (
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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We describe evidence for substance use as a risk factor for new-onset diabetes, prevalence of use in people with diabetes, evidence linking substance use with diabetes-related health outcomes, and evidence on the management of these co-occurring conditions.
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 13 January 2020Source: Medical Journal Armed Forces IndiaAuthor(s): Rajvir BhalwarAbstractMetabolic Syndrome (MetS) is a clustering of specific risk factors, namely, central obesity, raised blood pressure, impaired fasting glucose, raised triglycerides, and low levels of high-density lipoprotein-cholesterol (HDL-C). This constellation is triggered by insulin resistance and its resultant hyperinsulinemia. The two most important and universally agreed causes of insulin resistance are increased body fat (particularly central obesity) and physical inactivity. Other causes include certain gene...
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Authors: Colca J Abstract Introduction: NASH and type 2 diabetes (T2D) are clinical definitions that overlap and result from metabolic dysfunction caused by over-nutrition relative to metabolic need. This volume details drug development programs aimed at specific NASH pathology with a focus on liver outcomes; this commentary suggests a metabolic approach that should not be overlooked based on a new understanding of insulin sensitizers.Areas covered: The overlap of NASH and T2D with respect to metabolic syndrome are discussed in the context of new understandings of insulin sensitizers. Adverse clinical outcomes in s...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
(CBS Local) — Healthy habits such as exercising for at least 30 minutes a day or drinking in moderation can help you stave off diseases for an extra decade, according to new research. The study, published last week in the British Medical Journal, found that those who led a healthy lifestyle are more likely to be free of illnesses such as cardiovascular disease, cancer and type 2 diabetes. A healthy lifestyle was defined by those with at least four of the following five factors: Never smoking Healthy body mass index (BMI) of 18 to 25 Moderate alcohol intake (no more than a small glass of wine a day for women and a pi...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat Harvard Local TV talkers Source Type: news
ConclusionsResults revealed expert consensus and literature review agreement on a number of common modifiable risk factors for T2DM and dementia, as well as agreement on brain-related complications of diabetes. A number of other proposed shared risk factors did not reach consensus agreement suggesting a need for more high-quality studies to add to the evidence base.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
CONCLUSIONS: Healthier dietary habits are associated with cardiometabolic disease-free life expectancy between ages 50 and 85. PMID: 31927573 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
ConclusionThe health economic models identified in this review are associated with limitations primarily driven by a lack of NASH-specific data. Identified models also largely overlooked the intricate association between NASH and other conditions, including obesity and T2DM, and did not capture the increased risk of cardiovascular events associated with NASH. High-quality, transparent, validated health economic models of NASH will be required to evaluate the cost effectiveness of treatments currently in development, particularly compounds that may target other non-hepatic outcomes.
Source: PharmacoEconomics - Category: Health Management Source Type: research
Study after study reminds us that as challenging as it can be, sticking with healthy habits—eating right, exercising regularly, not smoking, maintaining a healthy weight, and controlling how much alcohol you drink—can help us to live longer. But tacking on extra years isn’t so appealing if some or most of them are riddled with heart disease, diabetes or cancer. In a 2018 study, an international group of researchers led by scientists at Harvard T.H. Chan School of Public Health found that adopting five healthy habits could extend life expectancy by 14 years for women and by 12 years for men: eating a die...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer diet Exercise Heart Disease Source Type: news
CONCLUSION: - RCT evidence supports the efficacy of some anti-hyperglycaemic agents (especially pioglitazone) in patients with NAFLD or NASH, though weight gain with pioglitazone may warrant caution. Further well-designed RCTs are needed to better characterize the efficacy and safety of monotherapy and combination therapy with anti-hyperglycaemic agents in patients with NAFLD. PMID: 31923578 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
ConclusionBoth FIB-4 and NFS scores have an acceptable clinical utility in the exclusion of advanced fibrosis in patients with NAFLD, regardless of the presence of type 2 diabetes. However, their usefulness in identifying advanced fibrosis is limited —especially in the absence of diabetes.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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