Blocking long noncoding RNA MALAT1 restrained the development of laryngeal and hypopharyngeal carcinoma

ConclusionIn summary, our deactivation model of MALAT1 disentangled the active function of it as a regulator of gene expression governing the hallmarks of laryngeal and hypopharyngeal cancer. Blocking this long non-coding RNA may restrain the development of laryngeal cancer.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research

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Conclusions: HART represents an attractive approach for patients with HNSCC where treatment intensification is indicated. PMID: 31519130 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Conclusion: Studies are essential for education and awareness aimed at reducing exposure to habit-forming substances.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instruments i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractHead and neck cancer is one of the most common cancers in the world, accounting for up to 30 –40% malignancies in India. Research is always on the lookout for parameters that help in early diagnosis of such disease and to explore the possibility of discovering such parameters that would assist in management of the disease by its potential to predict and prognosticate the disease. To estim ate serum ADA levels and to correlate with response to therapy and also to correlate between different clinical stages and serum ADA levels and to correlate HPV status to response to therapy. A prospective cohort study. 30 p...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
In this study, we analyzed the outcomes for patients treated with induction chemotherapy and subsequent definitive treatments.MethodsOperable patients with untreated oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma treated with induction chemotherapy were included in this retrospective study. We conducted induction chemotherapy using docetaxel, cisplatin and 5-fluorouracil and performed subsequent surgical treatment or radiotherapy according to the response to induction chemotherapy.ResultsA total of 65 patients were included in this study, and 50 patients (76.9%) had Stage IV tumors. The response to ind...
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Andersen AR, Bjerring OS, Godballe C, Detlefsen S, Mortensen MB Abstract INTRODUCTION: Patients with head and neck squamous cell carcinoma (HNSCC) are at an elevated risk of developing second primary malignancies (SPM). Our objectives were to estimate the excess risk of oesophageal and gastric SPMs in patients with malignancies of the pharynx or larynx and, additionally, to examine possible risk factors of developing SPMs. METHODS: Data on all patients treated for HNSCC with curative intent in the Region of Southern Denmark in the period between 1 January 2000 and 31 December 2010 were reviewed. A tota...
Source: Danish Medical Journal - Category: Journals (General) Tags: Dan Med J Source Type: research
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Source: Oral Diseases - Category: ENT & OMF Authors: Tags: Invited Commentary Source Type: research
This article is protected by copyright. All rights reserved.
Source: Oral Diseases - Category: ENT & OMF Authors: Tags: Invited Commentary Source Type: research
Conclusions The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThere is a syndrome of late neurological effects after RT, salvage surgery, and pharyngeal instrumentation that is associated with high morbidity and mortality. © 2015 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
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