Cancers, Vol. 11, Pages 1900: Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications
Cancers, Vol. 11, Pages 1900: Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications
Cancers doi: 10.3390/cancers11121900
Authors:
José Perea García
Julia Arribas
Ángel Cañete
Juan Luis García
Edurne Álvaro
Sandra Tapial
Cristina Narváez
Alfredo Vivas
Lorena Brandáriz
Sergio Hernández-Villafranca
Daniel Rueda
Yolanda Rodríguez
Jessica Pérez-García
Susana Olmedillas-López
Damián García-Olmo
Giulia Martina Cavestro
Miguel Urioste
Ajay Goel
Rogelio González-Sarmiento
Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and...
Source: Cancers - Category: Cancer & Oncology Authors: Jos é Perea García Julia Arribas Ángel Cañete Juan Luis Garc ía Edurne Álvaro Sandra Tapial Cristina Narv áez Alfredo Vivas Lorena Brand áriz Sergio Hern ández-Villafranca Daniel Rueda Yolanda Rodr íguez Jessica P érez-García Susana Olmedillas Tags: Article Source Type: research
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