Cancers, Vol. 11, Pages 1900: Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications

Cancers, Vol. 11, Pages 1900: Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications Cancers doi: 10.3390/cancers11121900 Authors: José Perea García Julia Arribas Ángel Cañete Juan Luis García Edurne Álvaro Sandra Tapial Cristina Narváez Alfredo Vivas Lorena Brandáriz Sergio Hernández-Villafranca Daniel Rueda Yolanda Rodríguez Jessica Pérez-García Susana Olmedillas-López Damián García-Olmo Giulia Martina Cavestro Miguel Urioste Ajay Goel Rogelio González-Sarmiento Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research