Early Onset Neurocirculatory Response to Static Handgrip is Associated with Greater Blood Pressure Variability in Women with Post-Traumatic Stress Disorder.

Early Onset Neurocirculatory Response to Static Handgrip is Associated with Greater Blood Pressure Variability in Women with Post-Traumatic Stress Disorder. Am J Physiol Heart Circ Physiol. 2019 Nov 22;: Authors: Yoo JK, Badrov MB, Parker RS, Anderson EH, Wiblin JL, Last Name CS, Suris A, Fu Q Abstract Post-traumatic stress disorder (PTSD) is a psychiatric illness that is more prevalent in women and accumulating evidence suggests a link between PTSD and future development of cardiovascular disease. The underlying mechanisms are unclear but augmented sympathetic reactivity to daily stressors may be involved. We measured muscle sympathetic nerve activity (MSNA), blood pressure (BP), and heart rate responses in 14 women with PTSD and 14 healthy women (controls) during static handgrip (SHG) exercise to fatigue at 40% of maximal voluntary contraction (MVC). Two min of post-exercise circulatory arrest (PECA) was followed immediately after SHG to fatigue. MVC and the time to fatigue during SHG did not differ between groups (both P>0.05). At the first 30 sec of SHG, women with PTSD showed augmented sympathetic neural (mean±SD, ∆MSNA burst frequency (BF): 5±4 vs. 2±3 bursts/30sec, P=0.02 and ∆MSNA total activity (TA): 82±58 vs. 25±38 a.u./30sec, P=0.004) and pressor (∆systolic BP: 10±5 vs. 4±3 mmHg, P=0.003) responses compared with controls. However, MSNA and BP responses at fatigue and during PECA were not different between g...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research