Effect of vitamin D levels on asthma control in adults

Several studies have shown that low serum levels of Vitamin D are linked to impaired lung function (Cassim, R., et al., Allergy, 2015. 70(4): p. 339-54.). Vitamin D may affect the course of asthma by effects such as anti-inflammatory effect, prevention of respiratory infections and reduction of steroid resistance (Iqbal, et al. J Investig Med, 2011. 59(8): p. 1200-2.). 35 healthy controls and 60 patients with asthma were included in the study between December 2016 and February 2017. Demographic characteristics and pulmonary function tests (PFT) were recorded and laboratory tests were measured. Asthma control test (ACT) was performed to asthmatics. Partipicians with decreased vitamin D level were consulted with Endocrinology Department for vitamin D replacement therapy. ACT and PFT were repeated after three months therapy in asthmatics. There were no significant difference between age, gender, BMI and demographic characteristics between both groups. Smoking status were similar. There was no significant difference between daily sun exposure, calcium containing diet and menauposal status. Serum phosphate, calcium, alkaline phosphatase, parathormone and 25(OH)D vitamin levels were similar. On the first admission, 71,7% of asthmatics were uncontrolled, while the rate of uncontrolled patients decreased to 13,2% after the post-replacement evaluation. There was a significant increase of ACT with respect to vitamin D replacemet therapy (22,4 ± 2,7 vs 16 ± 5,4, p=0,001). ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research