Mucoadhesive Thin Films For The Simultaneous Delivery Of Microbicide And Anti-Inflammatory Drugs In The Treatment Of Periodontal Diseases

Publication date: Available online 20 November 2019Source: International Journal of PharmaceuticsAuthor(s): Sim Yee Lim, Mali Dafydd, JieJi Ong, Launa A. Ord-McDermott, Emma Board-Davies, Kirsty Sands, David Williams, Alastair J. Sloan, Charles M. HeardAbstractThere is an unmet clinical need for new products to address the high percentage of the populous who present with periodontal diseases. Drug dose retention at the point of application would facilitate sustained release and more efficacious treatments. The aim of this study was to evaluate mucoadhesive polymeric thin films for simultaneous in situ delivery chlorhexidine and anti-inflammatory and analgesic drugs. Mucoadhesive thin films were prepared using a polymer mixture containing chlorhexidine (25 mg) ± diclofenac sodium (10 and 50 mg), and lidocaine hydrochloride (10 mg) or betamethasone dipropionate (10 and 50 mg). The films were assessed for in vitro drug release and localised tissue delivery, followed by determination of modulated prostaglandin E2 (PGE2) levels in ex vivo tissue and cytotoxicity using a HaCaT keratinocyte cell line. Antibacterial activity of the chlorhexidine/diclofenac film was determined against planktonic and biofilm bacteria associated with periodontal disease and dental plaque. Chlorhexidine release was consistently low (up to 10 % of initial loading) from all films, whereas the release of diclofenac, betamethasone and lidocaine exceeded 50 % within 30 min. The 50 mg betamethasone film relea...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research