Temporal relationship between 18 F-sodium fluoride uptake in the abdominal aorta and evolution of CT-verified vascular calcification

AbstractBackground Fluoride-18 sodium fluoride(18F-NaF) localizes in microcalcifications in atheroma. The microcalcifications may aggregate, passing the resolution threshold to visualize on computed tomography (CT). We evaluated serial NaF positron emission tomography (PET)-CT scans to determine the temporal relationship between vascular NaF uptake and CT evident calcification in the abdominal aorta.MethodsProstate cancer patients who had at least 3 NaF PET-CT scans over at least 1.5  years were retrospectively enrolled. Regions of interest were traced in the abdominal aorta on both PET and CT images, excluding skeletal NaF activity. The maximum standardized uptake value (SUVmax) of NaF and the density and volume of calcium (exceeding 130  HU) were summed and divided by the number of slices to produce the SUVmax/slice and the mm3·slice−1 of calcium.ResultsOf 437 patients, 45 patients met criteria. NaF uptake waxed and waned between scans, while the calcium volume plateaued or increased over time. NaF uptake correlated with calcium volume on the baseline scan (P = .60, 
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research

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A 29-year-old woman with stage IIBX classic Hodgkin's lymphoma presented with a 5.1  × 7.6-cm (mass to mediastinal ratio 0.34) anterior mediastinal mass and additional involvement of the subcarinal, posterior mediastinal, and right infraclavicular lymph nodes (Fig. 1). The patient was otherwise healthy, a lifelong nonsmoker, and European Cooperative Oncology Group performance s tatus 0. She had a National Comprehensive Cancer Network International Prognostic Score of 1. She received 2 cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), and interim positron emission tomography demonstr...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
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Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
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Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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