Leukocyte telomere length and coronary artery calcification in Palestinians

We examined the association of LTL with coronary artery calcification (CAC), which reflects the cumulative burden of coronary atherosclerosis, in an urban Arab sample of Palestinians, a population at high risk of CHD.Methods: Using a cross-sectional design, a random sample of East Jerusalem residents, comprising 250 men aged 45–77 and women aged 55–76 and free of CHD or past stroke, was drawn from the Israel national population register. LTL was measured by Southern blots. CAC was determined by 16-slice multidetector helical CT scanning using Agatston scoring. We applied multivariable logistic modeling to examine the association between sex-specific tertiles of LTL and CAC (comparing scores >100 vs.

Source: Atherosclerosis - July 22, 2013 Category: Cardiology Authors: Jeremy D. Kark, Hisham Nassar, Dorith Shaham, Ronit Sinnreich, Nehama Goldberger, Vartohi Aboudi, Naama R. Bogot, Masayuki Kimura, Abraham Aviv Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research