Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts.

The objective of this study was to identify proteins that are differentially expressed in the cystic wall tissues of ovarian endometriotic cysts, simple ovarian cysts, and in normal ovarian tissues. Specimens of ovarian endometriotic cyst wall tissue, simple ovarian cyst wall tissue, and normal ovarian tissue (six specimens per group) were collected from patients who received gynecologic surgery, respectively. Differentially expressed proteins related to the ovarian endometriotic cysts were screened by use of isobaric tags for relative and absolute quantitation (iTRAQ) combined with functional annotation and bioinformatics analyses. All differentially expressed proteins related to cysts were validated using immunohistochemistry methods in recurrent and non-recurrent ovarian endometriotic cyst. A total of 359 proteins were identified as up-regulated in ovarian endometriotic cyst groups when compared with both the normal ovary and simple ovarian cyst groups. The levels of 27 proteins were>two-fold higher in the ovarian endometriotic cyst group than that in the other two groups. Of note, the five most significantly upregulated proteins were Charcot-Leyden Crystal Galectin (CLC), Defensin, alpha 1 (DEFA1), S100 calcium-binding protein A9 (S100A9), S100 calcium-binding protein A8 (S100A8), and Ferritin Light Chain (FTL). Immunohistochemistry results showed that the changes of S100A9 and S100A8 were consistent with the results shown by iTRAQ. However, no similarity of CLC, DEFA1...
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research

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This report describes a case of heterotopic endometriosis in the inguinal region. What diagnostic and therapeutic strategies are effective for this benign tumor?ePlasty, Open Access Journal of Plastic Surgery
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news
Publication date: Available online 25 January 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Khadija Saidi, Shantanu Sharma, Bodil OhlssonAbstractEndometriosis and Irritable Bowel Syndrome (IBS) are common conditions among young women of reproductive age. The etiologies to the diseases are uncertain, but multifactorial pathophysiology has been proposed for each of them. Many studies have examined the two conditions separately, but the literature on the associations between endometriosis and IBS is sparse. However, there is an increasing amount of research on how endometriosis ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
ConclusionsClavien –Dindo complication grading was readily applicable to laparoscopic removal of endometriosis of all stages. Higher Clavien–Dindo grades correctly reflected clinically relevant complications and were associated with deep infiltrating endometriosis, stage IV endometriosis, bowel surgery, or hystere ctomy. Clavien–Dindo classification can be recommended for evaluation of laparoscopic endometriosis surgery outcome.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionAlthough our previous study suggests that serum sVCAM is a promising biomarker for diagnosing endometriosis, we found no significant differences in urine levels of sVCAM-1, sICAM-1, E-selectin and P-selectin between women with and without endometriosis. Other markers should be studied in an effort to establish a truly non-invasive, urinary test for diagnosing endometriosis.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: Available online 25 January 2020Source: Reproductive BioMedicine OnlineAuthor(s): Habiba Marwan, Gordts Stephan, Bazot Marc, Brosens Ivo, Benagiano GiuseppeABSTRACTThe availability of non-invasive diagnostic tests is an important factor in the renewed interest in adenomyosis, as the disease can now be more accurately mapped in the uterus without a need for hysterectomy. An agreed system for classifying and reporting the condition will enhance our understanding of the disease and is envisaged to enable comparing research studies and treatment outcomes. In this article, we review previous and more recent at...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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Source: Human Fertility - Category: Reproduction Medicine Authors: Source Type: research
Endometriosis and Irritable Bowel Syndrome (IBS) are common conditions among young women of reproductive age. The etiologies to the diseases are uncertain, but multifactorial pathophysiology has been proposed for each of them. Many studies have examined the two conditions separately, but the literature on the associations between endometriosis and IBS is sparse. However, there is an increasing amount of research on how endometriosis patients are likely to also have a diagnosis of IBS. Furthermore, endometriosis shares several features with IBS, such as low-grade inflammation and visceral hypersensitivity.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Review article Source Type: research
Publication date: Available online 23 January 2020Source: Reproductive BioMedicine OnlineAuthor(s): Jiayi Wu, Xiaoyan Yang, Jiaan Huang, Yanping Kuang, Qiuju Chen, Yun WangAbstractResearch questionDoes the preconception BMI affect the neonatal outcomes in patients with endometriosis who conceive with IVF?DesignThis retrospective study included 7086 women who delivered a singleton live birth through IVF between December 2006 and December 2017. Of these, 1111 were diagnosed with endometriosis by laparoscopy or laparotomy, while 5975 women received IVF treatment due to tubal factor or male factor infertility.Women were catego...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Hemoptysis is a well-known complication in people with cystic fibrosis (CF), which occurs in approximately 9% of CF individuals over a 5-year time period [1]. However, catamenial hemoptysis, expectoration of blood that coincides with menstruation, can be a unique manifestation in women with CF. Catamenial hemoptysis can be associated with thoracic endometriosis syndrome, (TES) which is estimated to occur in less than 6% of the general female population [2]. Studies examining catamenial hemoptysis in CF are limited.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Publication date: Available online 23 January 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Whitney Trotter Ross, Jordan M. Newell, Richard Zaino, Allen R. Kunselman, Gerald J. Harkins, Andrea S. BentonAbstractStudy ObjectiveTo evaluate the diagnosis of appendiceal endometriosis in coincidental appendectomy specimens using a standard versus modified histopathologic analysis.DesignProspective analysis of 300 consecutive patients undergoing coincidental appendectomy at time of a primary gynecologic procedure.SettingAcademic tertiary referral hospital in the Northeastern United States.PatientsWomen ages 22 to...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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