Polymethyl methacrylate (PMMA) grafted collagen scaffold reinforced by PdO–TiO2 nanocomposites

Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Mohan Vedhanayagam, Sureshkumar Anandasadagopan, Balachandran Unni Nair, Kalarical Janardhanan SreeramAbstractIn the past few decades, the design and fabrication of bio-scaffolds exhibiting structural stability in long-term and biocompatibility has received much attention in the field of tissue engineering application. In this direction, we have synthesized different mole ratio of PdO–TiO2 nanocomposites (1:1, 2:1 and 3:1 of Pd:Ti, size 5–11nm, 7–16 nm and 9–22 nm) through a simple single step sol–gel method. The obtained nanocomposites of different sizes were assimilated into poly (methyl methacrylate) grafted collagen biopolymer (g-PMMA-Collagen), resulting in a PdO–TiO2-g-PMMA-Collagen based scaffold. Physico-chemical properties and biocompatibility of g-PMMA-Collagen/PdO–TiO2-g-PMMA-Collagen scaffolds were analysed by using various techniques such as XRD, FT-IR, TGA, DSC, Universal Testing Machine, MTT, Alkaline phosphatase, Alizarin Red S staining assay and the obtained results were compared against pure collagen scaffold. Our results suggest that the incorporation of 1:1 mol ratio PdO–TiO2 nanocomposite (Size, 5–11 nm) offers a higher thermal stability (83.45 °C) and mechanical strength (Young's modulus 105.57 MPa) than the pure collagen scaffold (71.64 °C, 11.67 MPa). The PdO–TiO2 endowed scaf...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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