Effects of ascorbic acid treatment on developmental alterations in calcium-binding proteins and gamma-aminobutyric acid transporter 1 in the cerebellum of lead-exposed rats during pregnancy and lactation.

Effects of ascorbic acid treatment on developmental alterations in calcium-binding proteins and gamma-aminobutyric acid transporter 1 in the cerebellum of lead-exposed rats during pregnancy and lactation. J Toxicol Sci. 2019;44(11):799-809 Authors: Nam SM, Seo JS, Nahm SS, Chang BJ Abstract In the present study, we investigated the effects of lead (Pb) and ascorbic acid co-administration on rat cerebellar development. Female rats were randomly divided into the following groups: control, Pb, and Pb plus ascorbic acid (PA) groups. From one week prior to mating, female rats were administered Pb (0.3% Pb acetate in drinking water) and ascorbic acid (100 mg/kg, oral intubation). The chemical administration was stopped on postnatal day 21 when the morphology of the offspring's cerebellum is similar to that of the adult brain. The blood Pb level was significantly increased following long-term Pb exposure. Ascorbic acid reduced Pb levels in the dams and offspring. Nissl staining demonstrated that the number of Purkinje cells was significantly reduced following Pb exposure, while ascorbic acid ameliorated this effect in the cerebellum of the offspring. Calcium-binding proteins, such as calbindin, calretinin, and parvalbumin were commonly expressed in Purkinje cells, and Pb exposure and ascorbic acid treatment resulted in similar patterns of change, namely Pb-induced impairment and ascorbic acid-mediated amelioration. The gamma-aminobutyric acid transporter 1 (GABA...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research

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CONCLUSIONS In a rat model of maternal PCOS, exposure to androgens in utero resulted in dysbiosis of the intestinal microbiota and metabolic disorders of the newborn female rats. PMID: 31815927 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONSThe study does not provide evidence that web ‐based RLP influences contraceptive behaviors in insured women outside of the clinical setting. Further research is needed to identify strategies to help women of reproductive age identify contraceptive methods that meet their needs and preferences.
Source: The Guttmacher Institute - Category: International Medicine & Public Health Authors: Source Type: news
In this study, we aimed to comprehensively examine the population frequency and phenotypic profile of B cells over the course of murine pregnancy. Our results demonstrated a significant expansion in B cells within the uterus during the peri-implantation period, accompanied by alterations in B cell phenotype. Functional evaluation of uterine B cells purified from pregnant mice at day 5.5 post-coitus established their regulatory capacity as evidenced by effective suppression of proliferation and activation of syngeneic CD4+ T cells. Flow cytometric analysis revealed that the uterine B cell population has an expanded pool of ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The paper claimed that millions of women receiving the vaccine would never have had children.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
In this study, we explored the association between SHS, biomarkers of OS (BOS) and AGMs among normotensive pregnant women (NTN-PW) in a Ghanaian Suboptimal Health Cohort Study (GHOACS). This comparative GHOACS recruited 593 NTN-PW from the Komfo Anokye Teaching Hospital, Ghana. SHS was measured using a Suboptimal Health Status Questionnaire-25 (SHSQ-25). Along with the subjective SHS measure, objective BOS: 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-epiprostaglandinF2 alpha (8-epi-PGF2α), total antioxidant capacity (TAC), and AGMs: vascular endothelial growth factor-A (VEGF-A), soluble fms-like tyrosine kinase receptor 1...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
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Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
UNITED NATIONS, Geneva– Memory Banda, 23, knows how to change the world: by refusing to stay silent. Ms. Banda grew up in Malawi in an area wherechild marriage,sexual violence andearly pregnancy were common. “In my childhood, I had seen a lot of girls dropping out of school, getting pregnant, forced into marriages and sexually violated,” she recalled recently in an interview with UNFPA. 
Source: UNFPA News - Category: International Medicine & Public Health Authors: Source Type: news
Authors: Beltrán Rosel A, Sanjoaquín Conde I, Pérez Muñoz A, Alcalá PM, Marta CB, Irigoyen von Sierakowski A Abstract Strongyloides stercoralis is a parasitic nematode with a worldwide distribution. It can go from an asymptomatic infection to a life-threatening hyperinfection syndrome. Here, we report a case of intestinal obstruction due to S. stercoralis in a pregnant woman. This condition, as well as severe strongyloidiasis in pregnant women, is seldomly reported. In this case, Human Tlymphotropic Virus 1 (HTLV-1) coinfection was confirmed, a well-known risk factor for a more se...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Condition:   Acceptance and Commitment Therapy Intervention:   Other: Acceptance and Commitment Therapy Sponsors:   Southern Methodist University;   Jerry M. Lewis, M.D. Mental Health Research Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Umbilical Cord Clamping Intervention:   Other: Documentation of Maternal blood loss and neonatal outcome Sponsor:   Cairo University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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