Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments

Publication date: Available online 9 November 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Abhishek Ankur Balmik, Rashmi Das, Abha Dangi, Nalini Vijay Gorantla, Udaya Kiran Marelli, Subashchandrabose ChinnathambiAbstractTau is the major neuronal protein involved in the stabilization of microtubule assembly. In Alzheimer's disease, Tau self assembles to form intracellular protein aggregates which are toxic to cells. Various methods have been tried and tested to restrain the aggregation of Tau. Most of the agents tested for this purpose have limitations in their effectiveness and availability to neuronal cells. We have tested melatonin, a neurohormone secreted by pineal gland and a well-known anti-oxidant, for its ability to interact with the repeat domain of Tau using ITC and NMR. In aggregation inhibition and disaggregation studies of repeat Tau, melatonin was found to modulate the aggregation propensity of repeat Tau at a concentration of 5000 μM and was more effective in dissolving preformed aggregates rather than acting as an aggregation inhibitor. However, there were no major conformational changes in Tau in presence of melatonin as observed in CD spectroscopy. On the basis of our findings, we are proposing a mechanism by which melatonin can interact with the repeat domain of Tau and exhibit its disaggregation effect.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
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Many patients with cognitive impairment have anxiety or depression, but standard treatments are difficult for people with memory issues.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Mental Health and Disorders Depression (Mental) Alzheimer ' s Disease Memory Dementia Psychology and Psychologists Elderly Weill Cornell Medicine your-feed-healthcare Source Type: news
CONCLUSIONS: This study did not support an association between statin use and diagnostic conversion but suggested a possible association between statin use and cognitive change in EMCI. Additional randomized clinical trials of statins may be warranted in the prodromal EMCI stage of AD. PMID: 31806426 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
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Source: Neuroscience - Category: Neuroscience Source Type: research
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Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
Authors: Ghadiri-Sani M, Larner AJ Abstract The head turning sign was first described as such more than 20 years ago but only recently have empirical studies of the sign in large cohorts of patients being assessed for cognitive disorders been reported. Although precise operationalisation of the sign has differed between studies, nevertheless it appears to be frequently observed in cognitive clinic patient cohorts, more so in Alzheimer's disease than in other dementias and with an intermediate frequency in mild cognitive impairment. Head turning is an easily observed and categorised sign and may raise suspicion of t...
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Authors: Silverstein NM, Pitheckoff N, Dugan E Abstract Engaging gerontology students in research that hits "close-to-home" can have lasting benefits for them and their communities both professionally and personally. Since 2016, cohorts of undergraduate/certificate students in an online applied research in aging course have explored healthy aging in their Massachusetts' (MA) communities. The students utilized both primary and secondary data sources. First, they extracted data from the 2014-2015 healthy aging data report (HADR) community profiles of 367 MA communities. Then they conducted in-person in...
Source: Gerontology and Geriatrics Education - Category: Geriatrics Tags: Gerontol Geriatr Educ Source Type: research
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Source: Molecular Neurobiology - Category: Neurology Source Type: research
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Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Source Type: news
Conclusion: The evidence from the present study suggests that T allele of CD33 rs3865444 polymorphism is associated with LOAD in the studied Iranian population. PMID: 31799158 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
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