Impact of immunosuppressive therapy on brain derived cytokines after liver transplantation.

CONCLUSION: Our results imply that long-term treatment with CNI suppresses BDNF and PDGF expression, both crucial for neuronal signaling, cell survival and synaptic plasticity and thereby may lead to cognitive dysfunction and neurodegeneration.
PMID: 31669260 [PubMed - as supplied by publisher]

Source: Transplant Immunology - October 23, 2019 Category: Transplant Surgery Authors: Dirks M, Pflugrad H, Tryc AB, Schrader AK, Ding X, Lanfermann H, Jäckel E, Schrem H, Beneke J, Barg-Hock H, Klempnauer J, Falk CS, Weissenborn K Tags: Transpl Immunol Source Type: research